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Alkylation nucleophilic

Ylids can also serve as the alkylating nucleophiles an example is as follows (64). [Pg.6]

Nitrosamines require metabolic activation in order to produce a chemical species that will alkylate nucleophilic sites on a biomolecule such as DNA (1, . The crucial initial step in the... [Pg.39]

Tanaka et al.28 have synthesised a series of (S)-chiral Schiff bases as the highly active (yield 69-99%) and enatioselective (ee 50-96%) catalysts in the reaction of addition of dialkylzinc to aldehydes. The stereochemistry of the asymmetric addition was suggested. In a transition state when S-chiral Schiff base was used as chiral source, the alkyl nucleophile attacked Re face of the activated aldehyde and formed the R-configuration alkylated product [13]. [Pg.138]

Szabo S, Reynolds ES, Unger SH. 1982. Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis. J Pharmacol Exp Ther 223 68-76. [Pg.120]

Addition of an alkyl nucleophile leads, due to the loss of one double bond, to a decrease of electron affinity and a concomitant negative shift of the reduction potential of about 100 to 150 mV per lost double bond. One possibility to compensate for this negative shift is the introduction of an electron-withdrawing substituent such as cyanide. Reaction of liCN or NaCN with Cjq at room temperature generates the monoadduct anion that can be quenched with various electrophiles [6]. [Pg.86]

Ethylene oxide alkylates nucleophilic groups in biological macromolecules. Hemoglobin adducts have been used to monitor tissue doses of ethylene oxide (7). [Pg.1297]

Another type of alkylating species occurs in o. unsatu-nicd L urhonyl compounds. These compounds can alkylate nucleophiles by conjugate addition. Although there arc no established clinical agents of this type, many natural products active against experimental tumors contain a-methylcne lactone or er. unsatunitcd ketone functionalities. For... [Pg.397]

A few sulfate esters are chemically reactive and alkylate nucleophilic sites on macromolecules. This electrophilic characteristic implicates these conjugates as ultimate chemical toxicants. [Pg.307]


See other pages where Alkylation nucleophilic is mentioned: [Pg.684]    [Pg.8]    [Pg.157]    [Pg.473]    [Pg.144]    [Pg.79]    [Pg.144]    [Pg.394]    [Pg.303]    [Pg.303]    [Pg.7]    [Pg.331]    [Pg.577]    [Pg.135]    [Pg.297]    [Pg.230]    [Pg.259]    [Pg.1588]    [Pg.684]    [Pg.684]    [Pg.205]    [Pg.266]    [Pg.438]    [Pg.970]    [Pg.561]    [Pg.961]    [Pg.230]    [Pg.259]    [Pg.561]    [Pg.664]    [Pg.684]    [Pg.684]    [Pg.93]    [Pg.651]    [Pg.80]    [Pg.7]    [Pg.677]   
See also in sourсe #XX -- [ Pg.12 ]




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1 - Alkoxy alkyl sulfonates nucleophilic substitution

2-Alkyl-3-isothiazolinones, nucleophilic attack

Alkyl Halides Nucleophilic Substitution and Elimination

Alkyl Halides and Nucleophilic Substitution

Alkyl carbon centers, nucleophilic substitution

Alkyl derivatives carbon nucleophile reactions

Alkyl fluorides synthesis nucleophilic substitution

Alkyl groups steric hindrance to nucleophilic substitution

Alkyl groups, nucleophilic attack

Alkyl halides Compounds with halogen nucleophilic

Alkyl halides nucleophiles

Alkyl halides nucleophilic aliphatic

Alkyl halides nucleophilic substitution reactions

Alkyl halides with typical nucleophiles

Alkyl halides, from nucleophilic substitution

Alkyl halides, from nucleophilic substitution reactions

Alkyl halides, nucleophilic displacement

Alkyl halides, nucleophilic substitution

Alkyl iodides nucleophilic substitution

Alkyl ligands nucleophilic attack

Alkyl nucleophilic properties

Alkyl palladium nucleophilic displacement

Alkyl radicals nucleophilic character

Alkyl radicals nucleophilicity

Alkyl reaction with nucleophilic complexes

Alkyl sulfonates nucleophilic displacement

Alkyl sulfonates nucleophilic substitution

Alkylate cellular nucleophiles

Alkylation Reactions Nucleophilic Substitution

Alkylation hydroxyl groups nucleophilic

Alkylation nucleophilic alkylating agents

Alkylation nucleophilic allylic

Alkylation nucleophilic displacement

Alkylation of Carbon Nucleophiles by Conjugate Addition

Alkylation of Enolates and Other Carbon Nucleophiles

Alkylation of Nucleophilic Carbon Enolates and Enamines

Alkylation of carbon nucleophiles

Alkylation of nucleophiles

Alkylation reaction nucleophilic molecules

Alkylation, enolate ions nucleophilic substitution

Alkylation, enolate ions nucleophilicity

Alkylations and Additions of Other C-Nucleophiles to Imines

Alkylpyridines alkylation, nucleophilic

Allylic alkylation nucleophiles

Allylic alkylations nucleophiles

Azinium compounds, N-alkyl-, substituent displacement reaction with nucleophiles

Benzene, nucleophilic alkylation

Carbon nucleophiles alkyl halides

Diazonium ions alkyl, nucleophilic substitution

Enantioselective Alkylations and Additions of Other C -nucleophiles to Imines

Enzyme-Catalyzed Nucleophilic Substitutions of Alkyl Halides

Halide as a nucleophile alkyl halides

Hard Nucleophiles in the Rhodium-Catalyzed Allylic Alkylation Reaction

I Reactions of Alkyl Halides Nucleophilic Substitutions and Eliminations

Imine formation nucleophilic alkyl substitution

Iron alkyls, carbonylation reactions with nucleophiles

Ketones and Esters as Nucleophiles for Rhodium-Catalyzed Allylic Alkylation

Key Concepts—Alkyl Halides and Nucleophilic Substitution

Mechanism nucleophilic alkyl substitution

Metal alkyls, nucleophilic reactivity

Metal halide, nucleophilic alkylation

Modification of 3-alkyl substituents by nucleophilic substitution

Nucleophile alkyl

Nucleophile alkyl

Nucleophiles alkyl halide substitution reactions

Nucleophiles alkylations

Nucleophiles alkylations

Nucleophiles reaction with alkyl

Nucleophiles, alkylation

Nucleophiles, alkylation

Nucleophilic Abstraction in Hydrides, Alkyls, and Acyls

Nucleophilic Aliphatic Substitution Preparation of Alkyl Halides

Nucleophilic Alkylation of Iminium Ions and other Electrophiles

Nucleophilic Substitution of Alkyl Sulfonates

Nucleophilic aliphatic substitution alkyl sulfonates

Nucleophilic alkyl substitution

Nucleophilic alkyl substitution alcohols

Nucleophilic alkyl substitution allylic halides

Nucleophilic alkyl substitution benzylic halides

Nucleophilic alkyl substitution crown ether catalysis

Nucleophilic alkyl substitution enzyme catalyzed

Nucleophilic alkyl substitution epoxides

Nucleophilic alkyl substitution phase transfer catalysis

Nucleophilic allylation, alkali-metal alkyl

Nucleophilic attack alkyl halides

Nucleophilic substitution alkyl bromides

Nucleophilic substitution alkyl chlorides

Nucleophilic substitution in alkyl halides

Nucleophilic substitution phenolic oxygen alkylation

Nucleophilic substitution reactions of alkyl halides

Palladium-Catalyzed Nucleophilic Substitution and Alkylation

Piperidine nucleophilicity, -alkylation

Pyridazine nucleophilic alkylation

Pyridinium ions: nucleophilic alkylation

Pyrimidines, alkyl-, reactivity nucleophilic substitution

Quinolines nucleophilic 2-alkylation/arylation

Reactions of Alkyl Halides Nucleophilic Substitutions and Eliminations

Rhodium-Catalyzed Allylic Alkylation Reaction with Stabilized Carbon Nucleophiles

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