Alkyl derivatives carbon nucleophile reactions

Reactions with carbon nucleophiles, e.g. from ketones (73CR(C)(277)703, 74CR(C)(278)427), are sometimes accompanied by deacylation in situ to give alkyl derivatives, e.g. (106)... 

Monoanions derived from nitroalkanes are more prone to alkylate on oxygen rather than on carbon in reactions with alkyl halides, as discussed in Section 5.1. Methods to circumvent O-alkylation of nitro compounds are presented in Sections 5.1 and 5.4, in which alkylation of the a.a-dianions of primary nitro compounds and radial reactions are described. Palladium-catalyzed alkylation of nitro compounds offers another useful method for C-alkylation of nitro compounds. Tsuj i and Trost have developed the carbon-carbon bond forming reactions using 7t-allyl Pd complexes. Various nucleophiles such as the anions derived from diethyl malonate or ethyl acetoacetate are employed for this transformation, as shown in Scheme 5.7. This process is now one of the most important tools for synthesis of complex compounds.6811-1 Nitro compounds can participate in palladium-catalyzed alkylation, both as alkylating agents (see Section 7.1.2) and nucleophiles. This section summarizes the C-alkylation of nitro compounds using transition metals. 

Iodomethyltrialkyltin compounds, R3SnCH2I (from R3SnCl and ICH2ZnI), provide an entry to other functionally substituted organotin compounds. Reaction with nucleophiles such as R10, R1S, R 2N, or R 3P gives further a-substituted derivatives, and carbon nucleophiles can be used to locate the functional groups at more distant positions on the alkyl chain. Some examples are shown in Scheme 3. 

Reactions of allylic electrophiles with stabilized carbon nucleophiles were shown by Helmchen and coworkers to occur in the presence of iridium-phosphoramidite catalysts containing LI (Scheme 10) [66,69], but alkylations of linear allylic acetates with salts of dimethylmalonate occurred with variable yield, branched-to-linear selectivity, and enantioselectivity. Although selectivities were improved by the addition of lithium chloride, enantioselectivities still ranged from 82-94%, and branched selectivities from 55-91%. Reactions catalyzed by complexes of phosphoramidite ligands derived from primary amines resulted in the formation of alkylation products with higher branched-to-linear ratios but lower enantioselectivities. These selectivities were improved by the development of metalacyclic iridium catalysts discussed in the next section and salt-free reaction conditions described later in this chapter. 

Because enolate anions are sources of nucleophilic carbon, one potential use in organic synthesis is their reaction with alkyl halides to give a-alkyl derivatives of aldehydes and ketones ... 

We now wish to discuss displacements by nucleophilic reagents (Y ) on alkyl derivatives (RX). These are ionic or polar reactions involving attack by a nucleophile at carbon. A typical example is the reaction of hydroxide ion with bromomethane to displace bromide ion ... 

The synthesis starts with 2,4-dibromothiazole (40), a regioselective Pd(0)-catalysed cross coupling step introduces a substituent at the 2-position. Alkyl or aryl zinc halides were employed as the nucleophiles to give 41. The 4-bromothiazole derivative 41 was then converted into a carbon nucleophile either as a zinc derivative (Negishi conditions) or as a tin derivative (Stille conditions) which then underwent a second cross coupling reaction with 2,4-dibromothiazole (40) to give exclusively 2 ,4-disubstituted 2,4 -bithiazoles 42. 

Two major mechanisms have to be taken into consideration for the alkylation of Co -corrins. The classical mechanism of a bimolecular nucleophilic substitution reaction at carbon (the Co -corrin acts as a nucleophile) leads to /3-aUcylated Co -corrins with high diastereoselectivity. Secondly, an electron transfer-induced radical process (where the Co -corrin acts as a one-electron reducing agent) may also lead to cobalt alkylation. The observed formation of incomplete a-aUcylated Co -corrins under kinetically controlled conditions has been proposed to occur via this path. The high nucleophilic reactivity of Co -corrins and their diastereoselective nucleophilic reaction on the ( upper ) /3-face are not increased by the nucleotide function on the ( lower ) a-face rather they appear to be an inherent reactivity of the corrin-bound tetracoordinate Co -center. Among the organometallic B12 derivatives prepared to date, neopentylcobalamin, benzylcobalamin, and... 

While the addition/oxidation and the addition/protonation procedures are successful with ester enolates as well as more reactive carbon nucleophiles, the addition/acylation procedure requires more reactive anions and the addition of a polar aprotic solvent (HMPA has been used) to disfavor reversal of anion addition. Under these conditions, cyano-stabilized anions and ester enolates fail (simple alkylation of the carbanion), but cyanohydrin acetal anions are successful. The addition of a cyanohydrin acetal anion to l,4-dimethoxynaphthalene-Cr(CO)3 occnrs by kinetic control at C-/3 in THF/HMPA and leads to the O -diacetyl derivative after methyl iodide addition and hydrolysis of the cyanohydrin acetal. Monoacylation of 1,4-dimethoxynaphthalene-Cr(CO)3 has been achieved nsing the seqnence of reactions shown in eqnation (126). ... 

The substitution reactions of alkyl halides by carbon nucleophiles derived from alkynes and enolate anions provide major methods for the... 

Alkyl halides undergo nucleophilic substitution reactions by unimolecular (S l) and bimolecular (S 2) pathways. The substitution reactions of alkyl halides, and of derivatives of alcohols, utilize oxygen, nitrogen, sulfur and carbon nucleophiles. 

This methodology has been used to provide efficient protocols for the asymmetric allylic alkylation of p-keto esters, ketone enolates, barbituric acid derivatives, and nitroalkanes. Several natural products and analogs have been accessed using asymmetric desymmetrization of substrates with carbon nucleophiles. The palladium-catalyzed reaction of a dibenzoate with a sulfonylsuccinimide gave an advanced intermediate in the synthesis of L-showdomycin (eq 3). ... 

Nucleophilic addition to carbonyl functionalities undoubtedly represents one of the most important reactions of Grignard reagents. One such reaction is the alkylation of carbon dioxide to give carboxylic acid derivatives. Analogous reactivity is also observed between [TpBu jMgCH3 and CO2. which gives the acetate derivative [Tp ]Mg(f/ -02CCH3) [Eq (6)]. 

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