1- alkyl alcohol derivative

Thus, treatment of 319 with (i )-(-)MTPA-Cl using TEA as the base at -78 °C in 2-propanol allowed the fast and complete rearrangement to the corresponding esters 320 with an 88 12 diastereomeric ratio. Saponification 320 with LiOH led to the enantiomerically enriched l-(2-pyridinyl)alkyl alcohol derivative 321. 

Alkylated phenol derivatives are used as raw materials for the production of resins, novolaks (alcohol-soluble resins of the phenol—formaldehyde type), herbicides, insecticides, antioxidants, and other chemicals. The synthesis of 2,6-xylenol [576-26-1] h.a.s become commercially important since PPO resin, poly(2,6-dimethyl phenylene oxide), an engineering thermoplastic, was developed (114,115). The demand for (9-cresol and 2,6-xylenol (2,6-dimethylphenol) increased further in the 1980s along with the growing use of epoxy cresol novolak (ECN) in the electronics industries and poly(phenylene ether) resin in the automobile industries. The ECN is derived from o-cresol, and poly(phenylene ether) resin is derived from 2,6-xylenol. 

This fluorescent acid chloride can be used to form derivatives of alcohols, amines, and phenols. Using these fluorescent derivatives, an analysis of a series of n-alcohols from Ci to C4 was developed. A chromatogram produced by this technique is shown in Figure 3. Derivatives were also formed from ammonia, dimethylamine, and phenol. A derivative was formed from pentachlorophenol but was not fully characterized. The quantum yields of fluorescence of the alcohol derivatives of V were lower than those of the alkyl halide derivatives of III. 

HPLC Separation Conditions. Separations of alkyl bromide and alcohol derivatives were performed using an Altex Ultrasphere Cig S Mio>... 

The most representative non-ionic surfactants are the alkyl (alcohol) ethoxylates. These are adducts of a long-chain alcohol (12—18) with a variable number of EO units (3-11). Other non-ionic surfactants are derived from carbohydrates (glucoside and glucamide derivatives), organosilicones, fatty alcohols, and amides. Products in this category are as follows (compare also Table 1.2) ... 

ASs are made up of alkyl chains numbering 12 to 18 carbon atoms which are bound to a sulfate group. ASs are obtained by sulfation of fatty alcohols derived from palm oil, kernel oil and coconut oil, as well as from petrochemical raw materials. 

Organocopper-Mediated Alkylation of Propargyl Alcohol Derivatives... 

Similarly, ionized alcohols and ethers containing a chain of at least three contiguous carbon atoms attached at one end to the oxygen atom frequently expel water or the alcohol derived from the smaller alkyl group76-80. However, the corresponding ionized amines rarely eliminate ammonia or small alkylamines in great abundance. This contrast reflects energetic factors. Water and small alcohols are extremely stable molecules (AHf = —240 and —190 kJ mol-1, respectively, for water and methanol), but ammonia and methylamine are not particularly stable (AHf = —20 and —25 kJmol-1, respectively)82,83. Moreover,... 

The reaction of acceptor-substituted carbene complexes with alcohols to yield ethers is a valuable alternative to other etherification reactions [1152,1209-1211], This reaction generally proceeds faster than cyclopropanation [1176], As in other transformations with electrophilic carbene complexes, the reaction conditions are mild and well-suited to base- or acid-sensitive substrates [1212], As an illustrative example, Experimental Procedure 4.2.4 describes the carbene-mediated etherification of a serine derivative. This type of substrate is very difficult to etherify under basic conditions (e.g. NaH, alkyl halide [1213]), because of an intramolecular hydrogen-bond between the nitrogen-bound hydrogen and the hydroxy group. Further, upon treatment with bases serine ethers readily eliminate alkoxide to give acrylates. With the aid of electrophilic carbene complexes, however, acceptable yields of 0-alkylated serine derivatives can be obtained. 

The first examples of iridium-catalyzed allylic substitution [1] occurred between stabilized carbon nucleophiles and both alkyl- and aryl-substituted allylic alcohol derivatives with exceptional selectivity for the branched substitution product. 

Sinou and coworkers evaluated a range of enantiopure amino alcohols derived from tartaric acid for the ATH reduction of prochiral ketones. Various (2R,iR)-i-amino- and (alkylamino)-l,4-bis(benzyloxy)butan-2-ol were obtained from readily available (-I-)-diethyl tartrate. These enantiopure amino alcohols have been used with Ru(p-cymene)Cl2 or Ir(l) precursors as ligands in the hydrogen transfer reduction of various aryl alkyl ketones ee-values of up to 80% have been obtained using the ruthenium complex [93]. Using (2R,3R)-3-amino-l,4-bis(benzyloxy)butan-2-ol and (2R,3R)-3-(benzylamino)-l,4-bis(benzyloxy)butan-2-ol with [lr(cod)Cl]2 as precursor, the ATH of acetophenone resulted in a maximum yield of 72%, 30% ee, 3h, 25 °C in PrOH/KOH with the former, and 88% yield, 28% ee, 120 h with the latter. 

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