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Alanine: amino transferase

Oral dose of 1000, 2500, or 4000 mg/kg BW maintained at 22°C or minus 5°C for 10 h after dosing No deaths. Mild intoxication and elevated plasma alanine amino-transferase activity holding temperature did not affect toxicity 8... [Pg.1117]

Liver injury is clinically defined as an increase of serum alanine amino transferase (ALT) levels of more than three times the upper limit of normal and a total bilirubin level of more than twice the upper limit of normal [4]. The clinical patterns of liver injury can be characterized as hepatocellular (with a predominant initial elevation of ALT), cholestatic (with an initial elevation of alkaline phosphatase) or mixed. The mechanisms of drug-induced hepatotoxicity include excessive generation of reactive metabolites, mitochondrial dysfunction, oxidative stress and inhibition of bile salt efflux protein [5]. Better understandings of these mechanisms in the past decades led to the development of assays and models suitable for studying such toxic mechanisms and for selecting better leads in the drug discovery stage. [Pg.345]

Hepatic Effects. A study that measured levels of several liver enzymes (alanine amino transferase, aspartate amino transferase, gamma glutamyl transferase, and alkaline phosphatase) found no significant differences between workers exposed to silver and insoluble silver compounds and those with no history of silver exposure (Pifer et al. 1989). [Pg.28]

Murphy et al. (1964) found increased activities of alkaline phosphatase in livers of rats exposed to 35 ppm formaldehyde for 18 hours and suggested that formaldehyde may be hepatotoxic. More recent animal studies, however, have found no consistent evidence for formaldehyde-induced hepatotoxicity. Woutersen et al. (1987) found statistically significant increased levels of aspartate amino transferase, alanine amino transferase, and alkaline phosphatase in plasma of rats exposed to 20 ppm, (but not to 10 or 1 ppm) 6 hours/day, 5 days/week for 13 weeks, but found no exposure-related microscopic lesions... [Pg.87]

Hepatic Effects. Workers exposed chronically to 0.01-0.5 mg/m of vanadium dusts had normal serum levels of four enzymes (serum alkaline phosphatase, alanine amino- transferase, aspartate aminotransferase, and lactate dehydrogenase) that are commonly used to detect possible liver damage (Kiviluoto et al. 1981a). [Pg.19]

Prasad et al. [191] based their CDT calculation of Tf separated by CZE on the ratio of the area of disialo-Tf (they did not detect asialo-Tf) to the area of total Tf in the sample. On the basis of this index and with a control population of social drinkers, they established a CDT cutoff value. This cutoff value was exceeded by the majority of alcohol abusers studied. This CDT measurement was compared with other alcohol abuse markers (e.g., aspartate amino transferase, alanine amino transferase, and others) and it was found to be the most specific one. [Pg.682]

ALAT = alanine amino transferase, ASAT = aspartate amino transferase, LDH = lactate dehydrogenase, LDL = low-density lipoprotein, VLDL = very low-density lipoprotein, HDL = high-density lipoprotein. [Pg.85]


See other pages where Alanine: amino transferase is mentioned: [Pg.72]    [Pg.97]    [Pg.76]    [Pg.138]    [Pg.97]    [Pg.59]    [Pg.121]    [Pg.54]    [Pg.88]    [Pg.485]    [Pg.112]    [Pg.6]    [Pg.58]    [Pg.232]    [Pg.215]    [Pg.4]    [Pg.175]    [Pg.380]    [Pg.138]   
See also in sourсe #XX -- [ Pg.174 , Pg.175 , Pg.178 , Pg.226 , Pg.255 ]

See also in sourсe #XX -- [ Pg.295 ]

See also in sourсe #XX -- [ Pg.112 ]

See also in sourсe #XX -- [ Pg.380 , Pg.405 , Pg.435 ]




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Alanines, /3-amino

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