Aged garlic extracts

Garlic oil and S-allyl-cysteine sulfoxide (Alliin), a garlic compound, exhibited similar antioxidant properties. Aged garlic extract prevents ischemia and reperfusion injuries to the heart and brain. 

ATTENUATION OF ISCHEMIC BRAIN DAMAGE BY AGED GARLIC EXTRACTS... 

Numagami, Y., Sato, S., and Ohnishi, S.T., Attenuation of rat ischemic brain damage by aged garlic extracts a possible protecting mechanism as antioxidants, Neurochem. Int., 29, 135-143, 1996. 

Fresh garlic contains no iV -fructosylarginine however, in the manufacture of aged garlic extract (over 10 months or so), it increases progressively,24 providing potent... 

N. Ide, M. Ichikawa, K. Ryu, K. Ogasawara, J. Yoshida, S. Yoshida, T. Sasaoka, S.-I. Sumi, and H. Sumiyoshi, Antioxidants in processed garlic. II. Tetrahydro-b-carboline derivatives identified in aged garlic extract, in G, 2002, 449 150. 

Borek, C. 2001. Antioxidant health effect of aged garlic extract. J. Nutr. 131, 1010S-1015S. 

Munday, J.S., Jamesm, K.A., Fray, L.M., Kirkwood, S.W., and Thompson, K.G. 1999. Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation. Atherosclerosis 143, 399-404. 

Rahman, K. and Billington, D. 2000. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J. Nutr. 130, 2662-2665. 

Ryu, K., Ide, N., Matsuura, H., and Itakura, Y. 2001. N alpha-(l-deoxy-D-fructos-l-yl)-L-arginine, an antioxidant compound identified in aged garlic extract. J. Nutr. 131, 972S-976S. 

A -Acetyl cysteine (amino acid, thiol) Aged garlic extract (= AGE) (thiols)... 

Kyolic Aged Garlic Extract Kyolic HI-PO , 600-mg tablets AGE powder... 

Kyolic Reserve Aged Garlic Extract, 600-mg capsules AGE powder... 

Aged garlic extract has been shown in in vitro and animal studies to protect against liver toxicity from environmental substances, such as bromobenzene (72), protect against cardiotoxicity from doxorubicin (73), and improve age-related spatial memory deficits (74). A placebo-controlled human study showed that garlic may also be useful as a tick repellent (75). In addition, a double-blind, randomized, placebo-controlled human study showed that garlic supplements taken over a 12-week period in the winter significantly reduced the incidence of the common cold (p < 0.001), and reduced the duration of symptoms when they occurred (p < 0.001) (76). 

Borek C. Antioxidant health effects of aged garlic extract. J Nutr 2001 131 1010S— 1015S. 

Ide N, Lau BHS. Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine 1999 6(2) 125—131. 

Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors a dose-finding study on the effects of AGE on platelet functions. J Nutr 2001 131 980S-984S. 

Steiner M, Lin RS. changes in platelet function and susceptibility of lipoproteins oxidation associated with administration of aged garlic extract. J Cardio Pharm 1998 31 904-908. 

Horie T, Matsumoto H, Kasagi M, et al. Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med 1999 65 545-548. 

Wang BH, Zuzel KA, Rahman K, et al. Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. Toxicology 1999 132 215-25. 

Moriguchi T, Saito H, Nishiyama N. Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. Biol Pharm Bull 1996 19 305-307. 

Horie, T., Awazu, S., Itakura, Y. and Fuwa, T. (1992) Identified diallyl polysulfides from an aged garlic extract which protects the membranes from lipid peroxidation. Planta Med. 58 468 169. 

Ide, N., Nelson, A.B. and Lau, B.H. (1996) Aged garlic extract and its consituents inhibit copper-induced oxidative modification of low density lipoprotein. Planta Med. 63 263. 

Ray B, Chauhan NB, Lahiri DK (2011) The "Aged Garlic Extract " (AGE) and one of its active ingredients S-Allyl-LCysteine (SAC) as potential preventive and therapeutic agents for Alzheimer s Disease (AD). Curr Med Chem 18 3306-3313... 

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