Aesculus saponins

Escin lb (triterpene saponin) Aesculus chinensis (Hippocastanaceae) HIV-1 protease (50 pM) [56]... 

Aescin is a complex mixture of triterpene saponins prepared from the seeds of the horse chestnut, Aesculus hippocastanum. It consists of a water-soluble fraction (alpha-aescin) and a water-insoluble fraction (beta-aescin). 

HORSE CHESTNUT, AescuU semen is the seed of Aesculus hippocastanum (L.), family Hippocastanaceae. The seed contains a triterpene saponin mixture usually referred to as Aescin. Aescin gives prolonged... 

Ginsenoside Ro (Fig.(l)) has been screened for activity in experimental models of inflammation. This saponin (10, 50, 200 mg/kg, p.o.) inhibited an increase in vascular permeability induced by acetic acid in mice and reduced an acute paw oedema in rats induced by carrageenin [88], Similar results were obtained in these experiments with pure escins la, lb, Ila, lib (50-200 mg/kg) (57-57c) from Aesculus hyppocastanum [88a]. According to structure-activity relationship studies, the acyl groups were essential in the escins. 

The tincture of Aesculus hippocastanum seeds has been used successfully for haemorrhoids and venous congestion. Aescin, a mixture of oleanane triterpene saponins with a yield of about 13% relative to the crude drug weight, shows anti-inflammatory action, and it is administered orally for clinical use [19]. 

Commonly encountered esters are angelates and tiglates, which are found, for example, in the saponins from horsechesnut Aesculus glabrus L. (22). Table 2 lists some of the acids present in saponins with their representative references. 

Eocin. A mixture of more than 30 different saponins isolable from (horse) chestnuts (Aesculus hippocasta-num, Hippocastanaceae) consisting mainly (up to... 

CAS 6805-41-0 EINECS/ELINCS 229-880-6 Definition Saponin occurring in the seed of the horse chestnut tree, Aesculus hippocastanum Empirical C54H84O23... 

Unsaturated and hydroxylated triterpenes and steroids give colored products with aromatic aldehydes in strong mineral acids, with acetic anhydride in sulfuric acid, and with inorganic salts (cerium(IV) sulfate and antimony(III) chloride, for example) in an acidic solution. These reactions have been used as the basis for determination of saponins. The analysis of Ginseng radix (Panax ginseng, Araliaceae) in Pharmacopoeia Helvetica VII, for example, relies on reaction with glacial acetic acid/sulfuric acid and spectrophotometric determination at 520 nm of the red product. The jS-aescine component of horse chestnut (Aesculus hippocastanum, Hippocastan-aceae) saponin can be determined spectrophoto-metrically after treatment with a mixture of iron(III) chloride, acetic acid, and sulfuric acid. 

Facino RM, Carini M, Stefani R, Aldini G, Saibene L. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus factors contributing to their efficacy in the treatment of venous insufficiency. Arch Pharm (Weinheim) 328(10), 720-724, 1995. 

Triteipenoid glycosides (saponins) Escin Aesculus hippocastanum L. [43]... 

Carini M., R. Maffei Pacino, A. Brambilla, R. Stefani and C. Scesa, 1994, Anti-Hyaluronidase and Anti-Elastase Activity of Saponins of Hederal helix, Aesculus hippocastanum and Ruscus acue-lastus An Explanation of Their Efficacy in the Cosmetic Treatment of Liposclerosis, 18th International I.F.S.C.C. Congress, Poster presentation, Fondazione ClNl, Venezia, Italy. 

---