Aesculus hyppocastanum

Ginsenoside Ro (Fig.(l)) has been screened for activity in experimental models of inflammation. This saponin (10, 50, 200 mg/kg, p.o.) inhibited an increase in vascular permeability induced by acetic acid in mice and reduced an acute paw oedema in rats induced by carrageenin [88], Similar results were obtained in these experiments with pure escins la, lb, Ila, lib (50-200 mg/kg) (57-57c) from Aesculus hyppocastanum [88a]. According to structure-activity relationship studies, the acyl groups were essential in the escins. 

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