Advanced ChemTech Model 90 peptide synthesizer

There are four 90 ml reservoirs in which to place predissolved amino acid solutions or amino acids as dry pow-ders for on-line dissolution. Depending on the selected coupling method, protected amino adds can be preactivalcd in the amino acid reservoirs followed by transfer to the reaction vessel for acylation. Alternatively, amino acids can be added directly to the reaction vessel for in situ activation. The system is supplied with seven solvcnt/rcagcnt reservoirs three 1 gallon and four 1 litre) to allow solutions for general 

The system operates via mouse-driven software with a DOS-based IBM PS/2 compatible computer equipped with standard protocols that can be further modified by the user. 

5 Advanced ChemTech Model 400 production-scale synthesizer 

The system is usually customized to cover the specific needs of a laboratory (additional solvents, safety features, and integration into existing laboratory infrastructure) and is of stainless steel construction with only glass and Teflon contact areas to allow operation in a clean room environment. Software and hardware are designed specifically for compliant operation. 

Under the pumped flow solvent conditirms in continuous-flow instrumentation, polystyrene resins can create high pressures that can halt a synthesis. To use these polymeric supports in continuous-flow systems, a minimum of a 4 1 ratio of glass to polystyrene bead is required. I hc incorporation of polyethylene glycol spacers into polystyrene provides a support, namely PEG-PS, which is compatible with and recommended for continuous-flow systems. 

---

Figure 4. Advanced ChemTech Model 90 peptide synthesizer.

In 1989, Advanced ChemTech (ACT) introduced the Model 350 Simultaneous Multiple Peptide Synthesizer capable of assembling up to 96 peptides at scales from 5 to 50 pmol using the Fmoc method. Two different sized reaction vessels are available 600 pL and 1.5 mL. The first Model 350 was originally designed similar to the SMPS 350 by Zinsser, however during the next several years, ACT added additional features, such as an orbital shaker for resin agitation to differentiate the product. ... 

---