Liver adenosine triphosphatase

The catecholamines can play an important role in the short-term regulation of plasma potassium levels. Stimulation of hepatic a-adrenoceptors will result in the release of potassium from the liver. In contrast, stimulation of (32-adrenoceptors, particularly in skeletal muscle, will lead to the uptake of potassium into this tissue. The (32-adrenoceptors are linked to the enzyme Na"", K+ adenosine triphosphatase (ATPase). Excessive stimulation of these (32-adrenoceptors may produce hypokalemia, which in turn can be a cause of cardiac arrhythmias. 

Mitchell, P., and J. Moyle, Stoichiometry of proton translocation through the respiratory chain and adenosine triphosphatase systems of rat liver mitochondria. Nature 208 147, 1965. The initial observations that electron transport moves protons outward across the mitochondrial inner membrane and that ATP hydrolysis does the same. 

Total adenosine triphosphatase activity of rat liver +80 +62 +40 Activator... 

Amzel, L. M., and Pedersen, P. L. (1978). Adenosine triphosphatase from rat liver mitochondria Crystallization and x-ray diffraction studies of the F -component of the enzyme. / Biol. Chem. 253, 2067-2069. 

In some experiments concerned with the mechanism by which tryptophan acted to improve hepatic protein synthesis after toxic injury, the ability of tryptophan to stimulate hepatic mRNA synthesis, nucleocytoplasmic translocation of RNA in vitro, and nuclear envelope nucleoside triphosphatase activity after hepatotoxic injury was measured.188 Nucleoside triphosphatase (Mg2+-dependent adenosine triphosphatase, EC 3.6.1.3.1) was assayed since it is present in mammalian liver nuclear envelopes,224 and there is evidence that this enzyme is involved in nucleocytoplasmic translocation of RNA.221 All of these parameters were elevated significantly by tryptophan after agents such as actinomycin D, cordycepin, ethionine, puromycin, and hypertonic NaCl demonstrated a curative effect by tryptophan, but not after tryptophan following CC14, NaF, and sparsomycin demonstrated no improvement with tryptophan. These findings emphasized the importance of the role that tryptophan plays in stimulating the availability of cytoplasmic... 

II. Dinitrophenol-stimulated adenosine triphosphatase activity and fatty acid content of mouse liver mitochondria. Biochem, 5(12), 3904-3911. 

Enzymes, such as 7-GTP, glucose-6-phosphate (G-6-Pase), and canalicular adenosine triphosphatase (ATPase) have been generally used as markers for assaying initiated cell populations in liver carcinogenesis [15]. In order to confirm the essential similarity of foci induced by DEN plus ABA to those observed after DEN alone, a comparison of histochemical characteristics was made. The foci induced by DEN plus PH, typically showing positive for 7-GTP and periodic acid Schiff stain and negative for G-6-Pase and ATPase. 

AflSnity chromatographic purification 192 of adenosine triphosphatase from rat liver mitochondria Affinity chromatographic purification 193 of adenosine deaminase Affinity chromatographic purification 194 of histidinol dehydrogenase Purification of dehydrogenase 195... 

ALT AND AST. Alanine aminotransferase and aspartate aminotransferase are enzymes located in liver cells that leak out into the general circulation when liver cells are injured. Previously known as the SGPT (serum glutamic-pymvic transaminase) and the SCOT (serum glutaic-oxaloacetic transaminase), respectively ATPASE. Adenosine triphosphatase BALSAMS. Mixtures of resins that contain relatively large amounts of cinnamic or benzoic acid or their esters. Typical balsams are balsam Peru, balsam Tolu, styrax, and benzoin. Canada balsam, Oregon balsam, and copaiba balsam are not true balsams since they do not contain benzoic or cinnamic acid or their esters. Balsams are insoluble in water but soluble in alcohol... 

Ohta S, Tsuboi M, Yoshida M and Kagawa Y (1980) Inter subunit interaction in proton translocating adenosine triphosphatase as revealed by hydrogen exchange kinetics. Biochemistry 19t 2160-2164. Pullman ME and Monroy GC (1963) A naturally occuring inhibitor of mitochondrial adenosine triphosphtase, J. Biol. Chem. 238, 3762-3769. Rott R and Nelson N (1981) Purification and immunological properties of proton ATPase complexes from yeast and rat liver mitochondria, J. Biol. Chem. 256, 9224-9228. 

Rat. Male and female Sprague-Dawley rats, four to six days of age, were exposed by whole-body inhalation to concentrations of 0, 25, 40, 50, 80 and 125 ppm [0, 91, 146, 182, 292 and 456 mg/m3] 2-nitropropane (99% pure) for 6 h per day on five days per week for three weeks. One week later, a polychlorinated biphenyl (Clophen A50) was administered orally at a dose of 10 mg/kg bw tw ice per week for eight weeks. Thirteen weeks after the start of the experiment, the number of preneoplastic adenosine-5-triphosphatase-deficient foci in the liver was found to increase linearly with the exposure concentration, demonstrating the initiating activity of 2-nitropropane (Denk et al., 1990). 

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