Adenosine interactions

Dipyridamole is a vasodilator and interferes with platelet function via intracellular cyclic AMR Adenosine interacts with the adenosine receptors to cause... 

Goettl VM, Lindsey AE, Neff NH, Hadjiconstantinou M (2000) GMl ganglioside restores abnormal responses to acute thermal tmd mechanical stimuli in aged rats. Brain Res 858 380-385 Gomes JA, Li X, Pan H-L, Eisenach JC (1999) Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats. Anesthesiology 91 ... 

This section is mainly concerned with the class I antiarrhythmics, which also possess some local anaesthetic properties, and with class IH antiarrhythmics. Antiarrhythmics that fall into other classes are dealt with under beta blockers , (p.833), digitalis glycosides , (p.903), and calcium-channel blockers , (p.860). Some antiarrhythmics that do not fit into the Vaughan Williams classification (see Table 9.1 , (below)) are also included in this section (e.g. adenosine). Interactions in which the an-tiarrhythmic drug is the affecting substance, rather than the drug whose activity is altered, are dealt with elsewhere. 

We have found that the adenosine analogues, 3-deazaadenosine and 5 -deoxy-5 -S-isobutyladenosine, which are potent inhibitors of transmethylation, inhibit IgE-mediated histamine release when incubated with L-homocysteine thiolactone (16). In addition, we have found that exogenous adenosine, in the presence of an ADA inhibitor and L-homocysteine thiolactone, markedly inhibits IgE-mediated secretion from human basophils (16). Thus, histamine secretion can be inhibited by two separate effects of adenosine interaction with an A2 receptor linked to adenylate cyclase and inhibition of intracellular transmethylation. 

In addition, adenosine is implicated in sleep regulation. During periods of extended wakefulness, extracellular adenosine levels rise as a result of metabolic activity in the brain, and this increase promotes sleepiness. During sleep, adenosine levels fall. Caffeine promotes wakefulness by blocking the interaction of extracellular adenosine with its neuronal receptors. ... 

Transmembrane Signaling Drag-receptor Interaction G-protein-coupled Receptors Histaminergic System Adenosine Receptois... 

The major relaxing transmitters are those that elevate the cAMP or cGMP concentration (Fig. 3). Adenosine stimulates the activity of cAMP kinase. The next step is not clear, but evidence has been accumulated that cAMP kinase decreases the calcium sensitivity of the contractile machinery. In vitro, cAMP kinase phosphorylated MLCK and decreased thereby the affinity of MLCK for calcium-calmodulin. However, this regulation does not occur in intact smooth muscle. Possible other substrate candidates for cAMP kinase are the heat stable protein HSP 20, (A heat stable protein of 20 kDa that is phosphorylated by cGMP kinase. It has been postulated that phospho-HSP 20 interferes with the interaction between actin and myosin allowing thereby smooth muscle relaxation without dephosphorylation of the rMLC.) Rho A and MLCP that are phosphorylated also by cGMP kinase I (Fig. 3). 

Acyl-CoA Synthetase Adaptive Immunity Adaptor Proteins Addiction Addison s Disease Additive Interaction Adenosine Adenosine Receptors Adenoviruses Adenylate Cyclase Adenylyl Cyclases ADH ADHD... 

ATP interacts with sulfate ion (SO ) to form adenosine 5-phosphosulfate (APS) in a reaction mediated by the enzyme ATP sulfate adenylyl transferase. 

Ferre, S, Fredholm, BB, Morelli, M, Popoli, P and Fuxe, K (1997) Adenosine-dopamine receptor-receptor interaction as an integrative mechanism in the basal ganglia. Trends Neurosci. 20 482-487. 

Catalysis by flavoenzymes has been reviewed and various analogues of FAD have been prepared e.g. P -adenosine-P -riboflavin triphosphate and flavin-nicotinamide dinucleotide ) which show little enzymic activity. The kinetic constants of the interaction between nicotinamide-4-methyl-5-acetylimidazole dinucleotide (39) and lactic dehydrogenase suggest the presence of an anionic group near the adenine residue at the coenzyme binding site of the enzyme. ... 

G. Graf, and G. Lagally, Interaction of clay minerals with adenosine-5-phosphates. Clays Clay Min. 25 12 (1980). 

Theophylline is also considered an alternative to inhaled corticosteroids for the treatment of mild persistent asthma however, limited efficacy compared to inhaled corticosteroids, a narrow therapeutic index with life-threatening toxicity, and multiple clinically important drug interactions have severely limited its use. Theophylline causes bronchodilation through inhibition of phosphodiesterase and antagonism of adenosine and appears to have anti-inflammatory and immunomodulatory properties as well.36... 

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