Histaminergic system

Synaptic Transmission a-Adrenergic System Muscarinic Receptors Histaminergic System... 

Adrenerigic System Dopamine System Histaminergic System Antidepressant Dtugs... 

Dopamine System Histaminergic system Muscarinic Receptors Serotoninergic System Tachykinins and their Receptors... 

Transmembrane Signaling Drag-receptor Interaction G-protein-coupled Receptors Histaminergic System Adenosine Receptois... 

Hong, Z. Y., Huang, Z. L., Qu, W. M. et al. (2005). An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. J. Neurochem. 92 (6), 1542-9. 

Other activators of the histaminergic system may also be involved in wakefulness. The orexin (i.e. hypocretin) A and B neuropeptides were isolated from rat hypothalamic extracts. A mutation in the orexin-2 receptor gene was found to be associated with canine narcolepsy, and mice lacking the orexin peptide display increases in REM and NREM sleep and a decrease in wakefulness time during the active period of normal rodents. However, the exact role of orexin in physiological sleep and the mechanisms involved have not yet been elucidated. 

Huang, Z. L., et al. (2001). Arousal effect of orexin A depends on activation of the histaminergic system. Proc. Natl. Acad. Set USA 98, 9965-70. 

Many clinically available drugs that modify sleep-wake cycles and appetite act through the histaminergic system 262... 

FIGURE 14-2 The histaminergic system of the rat brain. (A) Frontal sections through the posterior hypothalamus showing the location of histaminergic neurons. Arc, arcuate nucleus DM, dorsomedial nucleus LM, lateral mammillary nucleus MM, medial mammillary nucleus MR, mammillary recess PM, premammillary nucleus 3V, third ventricle VMH, ventromedial hypothalamic nucleus. (Modified with permission from reference [5].)... 

Histaminergic neurons have been found in the hypothalamus or diencephalon of a variety of vertebrate brains, including those of fish, snake, turtle and bird. The brain histaminergic system of zebrafish has been studied in... 

In summary, H3 receptors play an important role in the histaminergic regulation of the secretion of ACTH and other POMC-derived peptides since their activation inhibits the hormone response to various physiological stimuli, which is in accordance with the finding that an inhibition of the histaminergic system by blockade of synthesis or postsynaptic receptors exert a similar effect as activation of H3 receptors. 

Histaminergic neurons may be involved in the mediation of the OT response to physiological stimuli. Thus, blockade of the histaminergic system by a-FMH or HI or H2 receptor antagonists inhibited the dehydration-induced increase in OT mRNA in the SON and peripheral OT release in male rats [73, Kjaer et al. (unpublished observations)] and the suckling-induced OT release in lactating female rats [32], Furthermore, suckling increased histidine decarboxylase mRNA in the tuberomammillary nuclei [32]. 

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