Adam probe

Bisperoxo methyltrioxorhenium complex is one of the most powerful oxidants in Baeyer-Villiger reactions. In the same paper, oxidation of Adam probe was performed in order to provide evidence for the nucleophilic character of this complex. 

Alternate Name thianthrene monosulfoxide, thianthrene-5-oxide, thianthrene monoxide, Adam probe. 

Adam and Lohray122 have used thianthrene 5-oxide (88) as a mechanistic probe in oxidations with transition metal peroxides. They oxidized 88 with various diperoxo complexes of chromium, molybdenum and tungsten and formulated a plausible mechanism on the basis of the products formed, 89 and 90. 

Adams C. FDA launches probe of drugs from overseas. Wall Street journal, 12 September 2000. 

Epe, B., Mutzel, P. and Adam, W. (1988). DNA damage by oxygen radicals and excited state species, a comparative study using enzymatic probes in vitro. Chem. Biol. Interact. 67, 149-165. 

Stratakis, M., Nencka, R., Rabalakos, C., Adam, W. and Krebs, O. (2002). Thionin-sensitized intrazeolite photooxygenation of trisubstituted alkenes substituent effects on the regioselectivity as probed through isotopic labeling. J. Org. Chem. 67, 8758-8763... 

Spaldin, V., Madden, S., Adams, D.A., Edwards, R.J., Davies, D.S. and Park, B. K. (1995) Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe. Drug Metabolism and Disposition, 23 (9), 929-934. 

J. D. McCarter, M. J. Adam, and S. G. Withers, Binding energy and catalysis. Fluorinated and deoxygen-ated glycosides as mechanistic probes of Escherichia coli (lac Z) p-galactosidase, Biochem. J., 286 (1992) 721-727. 

The EPR Spectroscopic D Parameter of Localized Triplet Drradicals as Probe for Electronic Effects in Benzyl-type Monoradicals (Adam,... 

In Studying asymmetric oxidation of methyl p-tolyl sulfide, employing Ti(OPr-/)4 as catalyst and optically active alkyl hydroperoxides as oxidants, Adam and coworkers collected experimental evidence on the occurrence of the coordination of the sulfoxide to the metal center. Therefore, also in this case the incursion of the nucleophilic oxygen transfer as a mechanism can be invoked. The authors also used thianthrene 5-oxide as a mechanistic probe to prove the nucleophilic character of the oxidant. 

Adam and coworkers have carried out several studies aimed at elucidating the geometry of the transition-state structure for the allylic alcohol epoxidation using chiral substrates as stereochemical probe (equation 38). The threo.erythro diasteroselec-tivities for the epoxidation of a set of methyl-substituted chiral allylic alcohols with A ... 

Grime, G.W. Watt, F. Beam Optics of Quadrupole Probe-Forming Systems, Adam Hilger Bristol, 1984. 

Addnl Refs A) C. Lenchitz, "Ice Calorimeter Determination of Enthalpy and Specific Heat of Eleven Organometallic Compounds , PATR 2224 ( 1955) B) R. Veliky et al, "Enthalpy Change, Heat of Fusion, and Specific Heat of Basic Explosives , PATR 2504(1959) c) L.M. Fingerson, "Research on the Development and Evaluation of a Two-Sensor.Enthalpy Probe , Thermo Systems Inc Rept ARL 64-161 (Oct 1964) [Contract AF 33(657)-9917] D) D.E. Adams,... 

Adam GC, Cravatt BF, Sorensen EJ. Profiling the specific reactivity of the proteome with non-directed activity-based probes. Chem Biol 2001 8 81-95. 

Centre at the same University. His research interests are electron transport, metal organic and semiconductor organic interfaces, and magnetic materials at the nanoscale. Together with Adam Foster from the Technical University of Helsinki he is the author of a book on the Theory of Scanning Probe Microscopes, which is published by Springer Scientific. 

A decade ago, while considerable data had been compiled on the kinetic measurement of dissociative recombination (DR) reactions of small polyatomic ions, laboratory information on the product distributions of such reactions was restricted to the results of a few merged-beam and stationary-afterglow studies on DR of C02 and of H( [157,158], and the first explorations of combined flow tube/Langmuir probe/spectroscopic detector techniques, independently pursued by Rowe and co-workers (at Rennes) [159,160] and by Adams and co-work-ers (at Birmingham, and subsequently Atlanta) [161, 162]. Considerable advances have since been made, both in measurement of recombination coefficients (particularly for larger ions) and in the elucidation of product distributions for a still small but growing sample of important IS ions. 

During this period, Laurie also investigated the preparation of radiolabeled, iodo and bromo sugars via carbohydrate boranes (with J.-R. Neeser), fluorescent probe-sugar conjugates (with M. Yalpani), sugar ferrocene derivatives (with M. J. Adam), and extended his studies of the conformations of polycyclic sugar derivatives. 

Fig. 3.9. Method used to study the diffuse reflectance of opaque samples in pulse radiolysis (Adams et al., 1991). The insert shows the method used to mount the sample. The electrons pass through the thin aluminium plate and the probe light through the quartz window. The scattered beam is analysed in the normal way with a monochromator, care being taken to exclude normal reflected light.

Adam Cohen (19 years old ) develops an electrochemical paint brush circuit that uses an STM probe to manipulate copper atoms on a silicon surface... 

Adams EW, Ueberfeld J, Ratner DM, O Keefe BR, Walt DR, Seeberger PH. Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions. Angew. Chem. Int. Ed. 2003 42 5317-5320. 

Ratner DM, Adams EW, Su J, O Keefe BR, Mrksich M, Seeberger PH. Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides. ChemBioChem 2004 5 379-382. 

Roth RM, Panoiu NC, Adams MM, Osgood RM, Neacsu CC, Raschke MB (2006) Resonant-plasmon field enhancement from asymmetrically illuminated conical metallic-probe tips. Opt Exp 14 2921... 

Certain aromatic analogues of natural amino acids can be used as potential fluorescent probes of peptide structure and dynamics in complex environments. The research team of M.L. McLaughlin undertook the gram scale synthesis of racemic 1- and 2-naphthol analogues of tyrosine. The synthesis of the 1-naphthol tyrosine analogue started with the Gattermann formylation of 1-naphthol using the Adams modification to afford the formylated product 4-hydroxy-1-naphthaldehyde in 67% yield. 

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