Synthetic Oligosaccharides

The synthesis of well defined and homogeneous structures does allow the study of interaction phenomena in different ways. For obvious reasons oligosaccharide syn- 

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R. Roy, D. Zanini, S. J. Meunier, and A. Romanowska, Syntheses and antigenic properties of sialic acid-based dendrimers, in P. Kovac, (Ed.), Synthetic Oligosaccharides Indispensable Probes for the Life Sciences, ACS Symp. Sen, 560, 1994, pp. 104-119. 

P. Kovac, Synthetic Oligosaccharides—Indispensable Probes for the Life Sciences, ACS Symposium Series 560, American Chemical Society, Washington, DC 1994 and papers therein. 

A. Hasegawa, Synthesis of sialo-oligosaccharides and their ceramide derivatives as tools for elucidation of biologic functions of gangliosides, Synthetic Oligosaccharides—Indispensable Probes for the Life Sciences. ACS Symp. Ser. 560 (P. Kovdc, ed.), ACS, Washington DC, 1994, p. 184. 

The specificity of the antiserum raised against the Lea neoglycoprotein (9) was determined by hapten-inhibition studies using synthetic oligosaccharides,72 and derivatives of bovine and horse serum-albumin to which the Lea trisaccharide had been attached.73 On the basis of hapten inhibition of precipitation, this antiserum was shown to be highly specific for the carbohydrate portion of the synthetic antigen,... 

I I Mousa SA, FengX, XieJ, et al. Synthetic oligosaccharide stimulates and stabilizes angiogenesis structure-function relationships and potential mechanisms, J Cardiovasc Pharmacol 2006 48 6-13. 

Protein Conjugates of Synthetic Oligosaccharide Fragments of Dextrans... 

Fio. 1. Geometric mean of serum IgG anti-LPS antibodies (in Eusa units) elicited by HSA conjugates of synthetic oligosaccharide fragments of the O-SP of Sh. dysenteriae type 1 in mice 7 days after the their s.c. injection, 2 weeks apart, each injection containing 2.5 lg of saccharides. (Reproduced from Proc. Natl. Acad. Sci. U.S.A., 96 (1999) 5194-5197, V. Pozsgay, C. Chu, L. Pannell, J. Wolfe, J. B. Robbins, and R. Schneerson, with permission from the publisher.)... 

Ratner DM, Adams EW, Su J, O Keefe BR, Mrksich M, Seeberger PH. Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides. ChemBioChem 2004 5 379-382. 

Pozsgay V, Brisson JR, Jennings JH, Allen S, Paulson JC. Synthetic oligosaccharides related to group B streptococcal polysaccharides. 5. Combined chemical and enzymic synthesis of a pentasaccharide repeating unit of the capsular polysaccharide of type III group B Streptococcus and one- and two-dimensional NMR spectroscopic studies. J. Org. Chem., 1991 56 3377-3385. 

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