Morpholines, fungicidal activity

The systemic morpholine fungicide Corbel with fenpropimorph as its active substance is frequently applied to cereal cropping. It is rapidly metabolized in soil to fenpropimorphic acid. For the assay of fenpropimorphic acid in soil, GC-MS coupling109 has been proposed. The GC technique was used to assure the best separation for the fenpropimorphic acid from the complex soil matrix. The MS technique is very sensitive and assures the best reliability of the analytical information. The same reliability is also achieved when the HPLC-MS tandem system is used for sulfonylurea herbicide assay in soil.110... 

Amorolfine [78613-35-17 is a molecule that is totally different from this group it is a morpholine derivative (15) (19). This substance has a broad-spectmm activity and has a fungicide effect at fairly low concentrations. The development of a nail varnish for treatment of onychomycoses could be very interesting. 

Since morpholine eompounds are typically bactericidal and fungicidal, different selenomorpholines 134-136 were synthesized and their antimicrobial activity was tested against Staphylococcus aureus. 

A second group of SBI fungicides, the morpholines and 3-phenylpropylamines, are especially active against cereal powdery mildews, but seem to-block more than one.Step in the pathway. They may inhibit A -A isomerase, A1 reductase,... 

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