Fluazinam fungicidal activity

Although fluazinam has a broad spectrum of fungicidal activity it is less potent on rusts and powdery mildews [72, 156] (in contrast to the dinitrophenols, which are generally most effective against powdery mildews) and has not been commercialized for use on cereal crops. It has, however, found wide application in other crops since its first launch in New Zealand in 1988. 

Akagi, T., Mitani, S., Komyoji, T. and Nagatani, K. (1995). Quantitative Structure-Activity Relationships of Fluazinam and Related Fungicidal N-Rhenylpyridinamines Preventive Activity Against Botrytis Cinerea. J.Pestic.Sci.,20,279-290. 

Further exploration of this area of chemistry by Ishihara resulted in the discovery that arylaminopyridines are also potent uncouplers [98]. These compounds possess moderate acaricidal activity, but are better fungicides than the diarylamines. Optimization of this class of chemistry resulted in the discovery of fluazinam (4) [151]. Not only is fluazinam one of the most potent uncouplers known [99, 126], it also shows a high level of reactivity with thiols, the chlorine atom on the highly electron-deficient phenyl ring being readily displaced [126,... 

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