ACTIS

Both compounds react by an S l mechanism and their relative rates reflect their acti vation energies for carbocation formation Because the allylic chloride is more reactive we reason that it ionizes more rapidly because it forms a more stable carbocation Struc turally the two carbocations differ m that the allylic carbocation has a vinyl substituent on Its positively charged carbon m place of one of the methyl groups of tert butyl cation... 

Carotenuto, M. Dell Isola, L. Crovini, A. Actis. Accuracy of commercial dew-point hvgrom-eters. ASHRAE Transactions, 101, (2), 1995. 

Enterprise in the synthesis of new local anaesthetics shows no sign of diminution and several useful reviews dealing with the correlation of structure and local anaesthetic action have been published of which that by Moore deals generally with the subject, while Gilman, Goodman, Thomas, Hahn and Priitting discuss structure and acti-vity in... 

Systems usually fluonnated by electropositive fluorine reagents include acti-vated alkenes (enol ethers, enol acetates, silyl enol ethers, and enamines), activated aromatic systems, certain slightly activated carbon-hydrogen bonds, and selected organometallics. 

Fluconazole (4) (s the first member of a new generation of orally acti ve antifungal agents, highly effective in the treatment of dermal and vaginal infections [6, 7] S-Fluorocyrtosine (5) is also used to treat serious systemic fungal infections [5]... 

In the past the presence of hazardous substances in soils was not a major public concern. In spite of the large number of documented hazardous waste sites in the United States, relatively few sites liave been cleaned up widi specific redevelopment in mind. Remedial actions usually are undertaken to contain or remove chemical contaminants little or no consideration is given to the ultimate use of the site. If land reuse is decided before the cleanup there may be an opportunity to tailor the cleanup acti ities to best suit the site rcde elopment. 

The sorption of plutonium on a variety of the common minerals of igneous rocks under groundwater conditions is illustrated in Figure 3 (57, 58, 59). For comparison the sorption of other acti-... 

The application of high tension (e.g. 20 kV, 0.5 MHz) in an evacuated sysl (0.2. .. 8 torr) causes the residual gas to form a highly ionized mixture of positive i negative ions, electrons, photons and neutral gas molecules. In the presence of acti sorbents this plasma reacts with the chromatographically separated substances to y reactive ions and radicals. 

Fig.1. Non-activated and activated PAMAM-dendrimers. Schematic diagram of a non-acti-vated (left) and activated dendrimer (middle). The right panel shows a magnification of the dendrimer branches...

The HIV-1 coreceptors CXCR4 and CCR5 bind to ligand members of a family of molecules known as chemokines, or chemotactic cytokines. While the hallmark function of these small proteins is the direction of leukocyte trafficking, they can also participate in cellular events such as activation and costimulation (Bajetto et al. 2(X)la). Members of the chemokine family can be classified as either homeostatic or inflammatory based on their temporal expression (Charo and Ransohoff 2006 Kim 2005). Although traditionally the CNS had been thought to be protected from immune acti-... 

Kohen, R., Yamamoto, Y., Cundy, K.C. and Ames, B.N. (1988). Antioxidant actis itv of carnosine, homocarnosine, and anserine present in muscle and brain. PrcK. Natl Acad. Sci. USA 85, 3175-3179. 

S. Perotto, E. Actis-Perino, J. Perugini, and P. Bonfante, Molecular diversity of fungi from ericoid mycorrhizal roots. Mol. Ecol. 5 123 (1996). 

T reatment Control (Boiled Enzyme) n Unit PCP- Li ke Acti v i ty Active Enzyme n Unit PCP -Like Activity... 

Morgen. B.A. and Morris, H.R. Identification of two related pentapeptides from the brain with potent opiate agonist acti vi ty. Nature (London) 258 577-579, 1975. 

The results demonstrate anticonvulsant properties of PCP and ketamine in two quite different seizure models. On the one hand, ketamine was effective in antagonizing several components of PTZ activity. Others have previously reported anti-PTZ effects of ketamine. However, the present results demonstrate that the anticonvulsant effects of ketamine against PTZ seizures closely resembled the effects of phenobarbital in that both compounds delayed clonic convulsions and prevented tonic extension. Moreover, a low dose of ketamine, which alone showed no anticonvulsant effect or overt behavioral changes, potentiated the anti-PTZ effects of phenobarbita 1. These findings suggest that ketamine possesses selective anticonvulsant properties. The anticonvulsant mechanism of action for phenobarbital is not known. However, the similarities between ketamine and phenobarbital, and the interaction between the two compounds, suggest a common mechanism or site of acti on. 

Rotarod Performance, Lethali ty Ri ghting Reflex, Convulsant Acti vi ty, and... 

The alternative pathway may become activated by lipopolysaccharides, endotoxin (sepsis), virus, fungi, immunoglobulin A-antigen (IgA-Ag) immunocom-plexes, and foreign material. These activate C3, after which the common pathway of complement activation takes place (Fig. 4). There are also a number of inhibitors that regulate and control complement activation. The most important are the Cl-esterase inhibitor (Cl-Inh) and the membrane attack complex inhibitor factor (MACIF CD59). In sepsis a relative deficiency of Cl-Inh has been reported. Administration of Cl-Inh to patients with septic shock attenuates complement acti-... 

H Fischer, B Illek, PA Negulescu, W Clauss, TE Machen. (1992). Carbachol-acti-vated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume. Proc Natl Acad Sci USA 89 1438-1442. 

Surfactant Type Source % Acti ve Equivalent Weight... 

The variation of the apparent activation energy with alloy composition is shown in Fig. 20. These results show very close agreement with those of Eley and Luetic in the Au-rich region, i.e., there is a fall in apparent acti-... 

For this purpose, perfluorooctanesulfonyl-tagged benzaldehydes were reacted with 1.1 equivalents of a 2-aminopyridine (or 2-aminopyrazine), 1.2 equivalents of an isonitrile, and a catalytic amount of scandium(III) triflate [Sc(OTf)3] under micro-wave irradiation in a mixture of dichloromethane and methanol (Scheme 7.85). A ramp time of 2 min was employed to achieve the pre-set temperature, and then the reaction mixture was maintained at the final temperature for a further 10 min. The fluorous tag constitutes a multifunctional tool in this reaction, protecting the phenol in the condensation step, being the phase tag for purification, and serving as an acti-... 

In the past several years, it has become apparent that with proper tuning of ligation, it is possible to prepare organome-tallic compounds of actinide elements with very high coordinative unsaturation and very high chemical reactivity (JJ./Jj2, J 3) In regard to exploring "nonclassical" modes of carbon monoxide acti-... 

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