Acrylate monomers, effect cells

In this study we investigated the activity of three acrylate monomers on HL-60 cells by examining of some functional parameters. Ours results clearly indicate that TEGDMA and Bis-GMA, in a dose-dependent manner, reduces cellular proliferation in HL-60 leukemia cell line. This antiproliferative effect of these monomers seems to depend on a cytostatic activity with a cytotoxic effect only at 0.6 and 0.775 mM concentrations. Moreover, the effect on cell proliferation appears higher than that observed with ATRA. HEMA, on the contrary, do not shows any effect on the cellular proliferation. All monomers induce the differentiation process of HL-60 cell line as indicated by the presence of CL activity which is strictly dependent on the appearance of respiratory burst in human myeloid tumour cell lines. 

Cemoits and Adhesives.— Information on the role of acrylic bone cements in joint prostheses has already been given (see p. 419). However two related papers are worthy of mention in this more general context. The first discusses the clinical influences on the release of monomer from bone cement" and the second is concerned with the fate of methyl methacrylate in blood." Bayne et al. have primarily concerned themselves with effects associated with the preparation of the methyl methacrylate dough moulding compound immediately prior to use and shown that this does affect the amount of monomer available for release into the blood stream. Rejke et aU on the other hand have used gas-liquid chromatography to study the relative concentrations of methyl methacrylate monomer in cells and plasma as a function of time. 

Abbasi et al. bulk- and surface-modified PDMS with poly(acrylic acid) using a sequential method for preparation of polymer interpenetrating networks of PDMS/acrylic acid, as shown in Figure 23.5 [1,26]. This was used as an effective biomaterial for cochlear implants. Cured PDMS was swollen when in contact with the monomer solution of acrylic acid, which contained the initiator as well as the crosslinker. The swollen PDMS was then kept under polymerization conditions to activate the initiator and the crosslinker. The curing after polymerization helped in formation of interpenetrating networks. These led to hydrophilic silicone polymer IPN that improved the material s cell adhesion to its surface. 

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