Acidic drugs chromatography

Gilges, M. (1997). Determination of impurities in an acidic drug substance by micellar electrokinetic chromatography. Chromatographia 44, 191 —196. [Pg.309]

Verenitch SS, Lowe CJ, Mazumder A (2006) Determination of acidic drugs and caffeine in municipal wastewaters and receiving waters by gas chromatography-ion trap tandem mass spectrometry. J Chromatogr A 1116 193-203... [Pg.239]

Electrokinetic chromatography was introduced to determine the separation and the partitioning behavior of various acidic drugs in microemulsions... [Pg.156]

Ibuprofen, an acidic drug, which has a pAia of 4.4, is analysed by chromatography ph ODS silica gel with a mobile phase consisting of acetonitrile/0.1 M acetate buffer pH 4.2 (40 60). [Pg.244]

Rodriguez I., J. B. Quintana, J. Carpinteiro, A. M. Cairo, R. A. Lorenzo, and R. Cela (2003). Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. Journal of Chromatography A 985 265-274. [Pg.282]

Ho, E.N.M., Leung, D.K.K., Wan, T.S.M. and Yu, N.H. (2006) Comprehensive Screening of Anabolic Steroids, Corticosteroids, and Acidic Drugs in Horse Urine by Solid-Phase Extraction and Liquid Chromatography-Mass Spectrometry. J Chromatopfr A, 1120, 38. [Pg.82]

Using aminopropyl-modified silica gel plates in a normal phase system, the retention behavior of 12 acidic drugs and biologically active aromatic acids was investigated by high-performance thin layer chromatography. [Pg.1086]

Brooks, K. E. and Smith, N. B. 1991. Efficient extraction of basic, neutral, and weakly acidic drugs from plasma for analysis by gas chromatography-mass spectrometry, Clin. Chem.,31 1975-1978. [Pg.220]

Kot, A. Sandra, R Venema, A. Sub- and supercritical fluid chromatography on packed columns A versatile tool for the enantioselective separation of basic and acidic drugs. J.Chromatogr.Sci., 1994, 32, 439-448... [Pg.762]

T. Hanai, R. Miyazaki, A. Koseki and T. Kinoshita, Computational chemical analysis of the retention of acidic drugs on a pentyl-bonded silica gel in reversed-phase liquid chromatography,/. Chramatagr. Set, 2004, 42, 354-360. [Pg.23]

T. Hanai and H. Homma, Chromatography in silica retention of acidic drugs on a guanidino ion-exchanger,/. Liq. Chromatogr. Relat Technal, 2007, 30, 1723-1731. [Pg.23]

For the QSRR of reversed-phase liquid chromatography, the contact surface area is important, and the selection of a model phase is difficult, but a simple model phase is satisfactory for the measurement of albumin-acidic drug binding affinity in ion-exchange liquid chromatography/ ... [Pg.184]

Figure 9.3 The relationship between log nK and log k values measured by reversed-phase and ion-exchange liquid chromatography for acidic drugs.

Further analysis was performed to estimate the albumin-acidic drug binding affinity log oRT values. The albumin-acidic drug binding affinity was measured at pH 7.40. The log k values measured at pH 7.40 correlated with the predicted log tiK" values from the literature. The following relationship was obtained, log tiK = 1.597 x(log A )+ 5.808, r= 0.887, n = 13. The log nAT values may be derived from log k values measured on a guanidino phase at pH 7.40. Therefore, the addition of k measured by reversed-phase liquid chromatography improved the correlation, as previously described. ... [Pg.237]

Maurer HH (1999) Systematic toxicological analysis procedures for acidic drugs and/or metabolites relevant to clinical and forensic toxicology and/or doping control. Journal of Chromatography B Biomedical Sciences and Applications 733 3-25. [Pg.711]

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