Acetylsalicylic acid interaction

As the solvent mixture also contained 225 mg of tetramethyl ammonium hydroxide pentahydrate per liter at a high water content (75%), the surface of the reverse phase would have been largely covered with the tetramethyl ammonium hydroxide pentahydrate. This would have acted as an adsorbed ion exchange stationary phase. It is clear that the free acids, salicylic acid, acetylsalicylic acid (aspirin) and benzoic acid were retained largely by ionic interactions with adsorbed basic ion exchanger and partly by dispersive interactions with the exposed reversed phase. The acetaminophen and the caffeine, on the other hand, being unionized substances, were retained only by dispersive interactions with the exposed reversed phase. 

Draw the structural formula of acetylsalicylic acid shown on p. 78 and highlight the types of interactions that may be formed between it and a protein receptor. 

Juarez-Olguin H, Jung-Cook H, Flores-Perez J, Asseff IL. Clinical evidence of an interaction between imipramine and acetylsalicylic acid on protein binding in depressed patients. Clin Neuropharmacol 2002 25(l) 32-6. 

The FDA has announced its intention to require alcohol warnings on all over-the-counter pain medications that contain acetylsalicylic acid, salicylates, paracetamol, ibuprofen, ketoprofen, or naproxen. The proposed warnings are aimed at alerting consumers to the specific risks incurred from heavy alcohol consumption and its interaction with analgesics. For products... 

Lau, A.H. Chang, C.W. Schlesinger, P.K. Evaluation of a potential drug interaction between sucralfate and aspirin. Clin.Pharmacol.Ther, 1986, 39, 151-155 [plasma pharmacokinetics extracted metabolites, salicylic acid, salicyluric acid a-phenylcinnamic acid (IS) gradient column temp 30] Mamolo, M.G. Vio, L. Maurich, V. Higb-pressure liquid chromatographic analysis of paracetamol, caffeine and acetylsalicylic acid in tablets. Salicylic acid quantitation. Farmaco.[Prat]., 1985, 40, 111— 123 [tablets simultaneous ac etcuninophen, caffeine, phenazone, salicylic acid]... 

Kaldestad E, Hansen T, Bradi HK. Interaction of indomethacin and acetylsalicylic acid as shown by the serum concentrations of indomethacin and salicylate. EurJ Clin Pharmacol (1975) 9,199-207. 

The classical non-steroidal anti-inflammatory drugs, except acetylsalicylic acid, bind competitively to cyclooxygenases (Fig. 5.86). Usually, a very strong ionic bond to Arg-120 is formed. Additional lipophilic interactions at the site of the channel narrowing or in the active pocket enhance the binding further, so that arachidonic acid can no longer access this pocket. [158]... 

Haematologic In a placebo-controlled, single-blind cross-over study of 3-day cycles separated by washout periods of at least 12 days in 30 healthy individuals, the interaction on antithrombotic effect between acetylsalicylic acid (ASA) and nsNSAIDs (including naproxen 500 mg twice daily, ibuprofen 600 mg daily, meloxicam 15 mg daily and etoricoxib 90 mg daily) taken 2h before ASA (320 mg) was evaluated. Ibuprofen and naproxen inhibited ASA s antithrombocyte effect below the nonresponse threshold. Etoricoxib and meloxicam did not cause relevant changes in ASA thrombocyte inhibition. Naproxen had an inherent weak thrombocyte inhibitory action below the ASA response threshold. This study showed that COX-1 affinity determines the pharmacodynamic interaction between NSAIDs and ASA on the main fxmctions of the thrombocyte adhesion and aggregation. Ibuprofen and also naproxen inhibited ASA s thrombocyte effect... 

Solid-phase basic dyes ai e also used for the study of their interaction with medical products nicotinic, aminocaproic, acetylsalicylic and ascorbic acids and for the establishing of the new methods of SPS determination in known medical products. 

---