Acetyl glycine

Diethyl ether, methyl n-propyl ether, diethylamine, N-methyl-1 -propanamine, acetone, allyl alcohol, dimethylformamide, propanamide, 2-methylpropan-amide, 2,2-dimethylpropanamide, benzamide, dichloromethane, toluene, ethyl N-acetyl-glycinate, -alaninate, -methioninate, and -aspartate, ethyl acetate, tetrahydrofuran... 

Laurence, P. R., and C. Thomson. 1981. A Comparison of the Results of PCILO and Ab Initio SCF Calculations for the Molecules Glycine, Cysteine and N-Acetyl-Glycine. Theoret. Chim. Acta (Berl.) 58, 121-124. 

Abstract—A brief review is given of earlier low temperature studies (4° 20°K of the hydrogen stretching mode of H bonded species. Evidence for sharpening of band structure is quoted (e.g., acetyl glycine, hydrate salts). In contrast are studies for which the band breadth has been found to be virtually independent of tsmoerature (H80 CH3OH). 

Acetyl glycine, Axlde (Azidoacetylglycine or Triazoacetylglycine), CHj.CO.NfNjJ.CHj7 COOH, mw 158.12, N35-44%. Explosive, un-distillable oil. Was prepd from glycine and azidoacetic acid... 

N-Acetyl-glycine ethyl ester 1.0x10"2 1.0 xlO2 0.008 8.0x10- ... 

Mono- and trimethoxyphenyl azolactone intermediates of Stepl were also prepared by the author by condensing the corresponding mono- or trimethoxy benzaldehyde with N-acetyl glycine and are described. 

PNA units consisting of either R- or 5-iV-(2-pyrrolidine-methyl)-iV-(thymine-l-acetyl)-glycine were synthesised, and targeted towards complementary RNA. It was found that the R-isomer bound with higher affinity to RNA than the 5-isomer. The positively charged (at physiological pH) and conformationally... 

Acetic anhydride is added to 3-fluorobenzaldehyde, N-acetyl glycine, and anhydrous sodium acetate in ethyl acetate. The reaction mixture is heated to 80 °C. After completion of the reaction, the mixture is cooled, water is added, and the resultant precipitate is filtered and washed. The crude azlactone intermediate is then treated with aqueous sodium hydroxide followed by acidification. The resultant precipitate is filtered, washed, and dried to provide the N-acetyl dehydro-3-fluorophenylalanine in 70% yield from the aldehyde on a 50 kg scale. 

Alternatively, 6 can be prepared from 4-fluorobenzaldehyde and N-acetyl glycine... 

The N- H dipolar/chemical shift spectra were observed for polycrystalline samples of [15N]acetylvaline, -[15N]glycyl-[15N]glycine, [15N]glycyl-[15N]glycine HC1- H20, [15N]acetyl-glycine, [7r-15N]-l-histidine HC1 H20, and [e-15N]tryptophan21 (Fig. 5). 

The filtrate and wash-water are evaporated to dryness at 50-60° in a vacuum on crystallization from boiling water (75 ml) the residue affords a further amount (20-30 g) of the acetyl-glycine, and still a little more (4-6 g) can be isolated from the mother liquor therefrom. The total yield thus reaches 104-108 g (89-92%). 

It is virtually unaffected when is substituted for in acetyl-glycine (Darmon and Sutherland, unpublished). 

Despite its low toxicity, there have been extensive toxicological studies on EGME. The subacute percutaneous administration of this compound in male rats dosed 5 days/week for 4 weeks resulted in testicular and bone marrow damage at doses of 1000 mg/kg/day (Eairhurst et al. 1989). HPLC and isotope- dilution analysis indicated that the major metabolites were methoxyacetic acid [625-45-6] and methoxy-acetyl glycin (Moss et al. 1985). Foster et al. (1986) proposed that 2-methoxyacetaldehyde [10312-83-1] was a possible metabolite that played an important role in EGME-induced testicular toxicity. The former produced specific cellular toxicity to pachytene spermatocytes in mixed testicular cell cultures. Subchronic vapor inhalation studies in rats and rabbits showed that overexposure to EGME produced adverse effects on testes, bone marrow, and lymphoid tissues... 

Dialanyl-cystine, 27. Diazo-acetyl-glycine ester, 15. Dibromopropionyl-cystine, 38. Diglycinimide, 20. 

The sequence includes six cysteine residues, two of which are involved in a disulfide bond, and the N-terminal residue of the protein is an acetylated glycine [52]. Ova has one glycosylation site and two phosphorylation sites [53]. Ova contains 32% p-sheets and 30% a-helix as determined by X-ray crystallography [54, 55]. Some evidences indicate that Ova molecules self-assemble depending on protein concentration and pH. Ova is monomer at concentrations lower than about 0.1% and forms oligomers (dimer, trimer and tetramer) at higher protein concentrations the association behaviour is favoured when pH decreases from a neutral value to the protein p/ [56]. 

II Conformations of N-Acetyl L Alanine N-Methyl Amide in CC and H2O and N-Acetyl Glycine N-Methyl Amide in CCI4... 

The purpose of this study has been to explore the possibility of theoretically predicting the conformation of a solute molecule in a dilute solution, by considering both intra-and inter-molecular interactions, where the latter term is meant to imply the solute-solvent interactions. Recently Beveridge et al. [1] have reported a study on the conformations of acetylcholine in solutions, in which intramolecular interactions were calculated by a molecular orbital method, and solvation energies were computed from the calculated solute properties and the experimental solvent parameters, following a method developed by Sinanoglu [2]. In the present study we consider two representative dipeptides, N-acetyl glycine N-methyl amide [3], and N-acetyl L-alanine N-methyl amide, whose conformations in inert solvents have been determined by NMR and infrared spectroscopic studies [4-8]. 

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