Testicular cells and

Tanphaichitr N, Sobhon P, Taluppeth N, Chalermisarachai P (1978) Basic nuclear proteins in testicular cells and ejaculated spermatozoa in man. Exp Cell Res 117 347-356... 

In the mid-pachytene stage of meiosis. Hit becomes preferentially enriched in testicular cells and contributes to up to 50% of the total chromosomal linker histones (Cole et al. 1986). The deletion of Hit has no effect on viability and fertility of mice (Drabent et al. 2000). It is not quite clear whether other HI variants are upregulated in pachytene spermatocytes of Hit-deficient animals and compensate for the loss of Hit (Drabent et al. 2003 Nayernia et al. 2005). Thus, very little is known about... 

Tanphaichitr, N., Sobhon, P., Taluppeth, N., and Chalermisarachai, P. (1978) Basic nuclear proteins in testicular cells and ejaculated spermatozoa in man. Exp. Cell Res. 117, 347-356. Palmer, D.K., O Day, K., and Margolis, R.L. (1990) The centromere specific histone CENP-A is selectively retained in discrete foci in mammalian sperm nuclei. Chromosoma 100, 32-36. 

LH complexes with receptors on the Leydig cell testicular membrane and stimulates the production of testosterone and small amounts of estrogen. 

Nylen P, Ebendal T, Eriksdotter-Nilsson M, et al. 1989. Testicular atrophy and loss of nerve growth factor-immunoreactive germ cell line in rats exposed to -hexane and a protective effect of simultaneous exposure to toluene or xylene. Arch Toxicol 63 296-307. 

Etoposide is an effective anticancer drug used in the treatment of small-cell lung cancer, testicular cancer and lymphomas. It is a semi-synthetic modification of the natural lignan podophyllotoxin, and contains three acetal linkages. Can you identify them ... 

Brown CD, Miller MG. 1989. Relationship between testicular cell culture age and susceptibility to 1,3-dinitrobenzene induced toxicity [Abstract], 28th Annual Meeting, Society of Toxicology, Atlanta, GA. 

Lloyd SC, Foster PMD. 1987. 1,3-Dinitrobenzene Toxicity and metabolism in rat testicular cell cultures. Arch Toxicol, SuppI 11 281-284. 

DBCP is a genotoxic in microbial and mammalian assays. The mechanism for DBCP-induced testicular toxicity may be related to direct DNA damage. Binding of DBCP metabolites to testicular cell DNA has been demonstrated. Alternatively, inhibition of sperm carbohydrate metabolism could also account for DBCP toxicity to epididymal sperm. 

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