A Real-World Example

At this point in the discussion, all the tools needed to solve the problem posed at the very beginning of this chapter are now at hand. The problem will be approached in steps. The first task is to scan through a file of RNAi results, collecting the genes that have anything to do with locomotion. Assume that the input file is named rnai. txt and contains lines in the following format each field is separated by a tab. 

The main challenge here is to search the Phenotype Summary field for results having to do with locomotion. This is a fuzzy sort of problem, best solved using Perl s pattern-matching facility. After scanning throngh the results for a while, we decide to search for any of the following keywords nncoordinated, paralysis, paralyzed, coils, coder, movement, kinky, and jerky. 

Once this is done, the contents of phenotype are compared to a regnlar expression. The regular expression is a series of alternatives, separated by the I character. Any phenotype that contains any of the strings listed will prodnce a match. Notice that some of the keywords have been shortened to rednce the length of the expression, as well as pull in some terms that may not have been anticipated. For example, paraly will match both paralysis and paralyzed, withont mnch 

USING PERL TO FACILITATE BIOLOG 1CAL ANALYSIS 

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The TVM takes into consideration the total time that the principal was tied up into the investment. For the shares that we purchased on 1/1/01, the 100 was tied up for one full year. This portion of the investment made 10% in one year. But the shares that were purchased on 12/1/01 tied up 100 for only one month, which is a significantly higher return than the 10% per year. In fact, if an investment gained 10% every month like the latter share purchase, it would gain 207.5% in one year TVM formulas give the most accurate ROI calculation possible. They are the same formulas used by large investors and lending institutions to evaluate capital expenditures and investment alternatives. Unfortunately, in a real-world example, you would normally be unable to calculate the true TVM-ROI because the calculations require the application of advanced numerical analysis. 

As a real-world example, if you describe what it means to be a parent, you re talking largely about your interactions with your children and the effects you have on one another. When you describe what it means to be an employee, that s a different role with a different set of interactions with an object described in different terms. But although the collaborations can be described separately, the fact is that every object usually plays a role in several collaborations perhaps you are both a parent and an employee. Each object conforms to the spec of its roles in the various collaborations it takes part in. 

Make connections. Try to relate what you are reading to things you already know or to a real world example. It might be helpful, for example, to make up a word problem, or draw a diagram or table, to clarify your understanding of what a problem is asking you to do. 

After this short introduction, we demonstrate our CORA spreadsheet solution with a real-world example (Figure 6). 

Here is a real-world example for illustrative purposes. Suppose you have a chemical information system that has to support both Molfile and Smiles structures and a business method in a business object has to get the mol-weight and molformula from the Molstructure objects to fulfill its responsibilities. A naive design is to have two versions of the business method one takes a Molfile structure object as input and another takes a Smiles structure as input (Figure 2.4). 

Our next step in understanding chemical change is to apply what we have learned about rates of reactions to explore what happens when a reaction is reversible. Let s take a look at a real world example that we can use to illustrate our main points. 

Which of the following is not a real world example of a phase change ... 

Most of the sequences performed well even on this short and moderately shimmed sample. Despite not optimizing the shims, almost every sequence was able to suppress sufficiently to acquire useful spectra with minimal baseline distortions even close to the solvent. The exception occurred for the WET style sequences. The WET family did not suppress nearly as well and required the gain to be reduced by 6 dB (vertical scale in the figure was increased to compensate) to prevent a receiver overflow and ADC error. However, WET and SWET are very easy to include in pulse sequences (e.g. during the recycle delay or mixing periods) and allow simple suppression of multiple frequencies using composite shaped pulses. The poor results may come from several sources (e.g. coding error, optimization error, etc.) and therefore may not represent a limitation of the pulse sequences. Alternatively, as a real world example, some sequences simply perform better on some spectrometers and users must be prepared to adapt when necessary. We have t)q)ically found WET to be extremely reliable and robust, but certainly not on this particular sample. 

For a real-world example of some of the difficulties involved in translational research, see Couzin, I. Magnificent obsession. Science 2005, 307, 1712-1715. 

A real-world example of the current and voltage for an autonomous urban lighting application is given in section 3.1.6. 

In Section 17.8, we saw that [2+2] cycloadditions become symmetry-allowed in the presence of UV light, and this Is just a real-world example of that process. This reaction changes the structure of DNA and causes genetic code alterations that ultimately lead to the development of cancer cells. 

Gas Turbine Engines (GTE) are a real world example of a complex and a highly dynamical system that is comprised of many interconnected components. GTEs are... 

In order to demonstrate our approach, we have applied it to a real-world example. We have partially re-engineered the existing realization of a torque-vectoring rear axle system by replacing pre-existing software safety mechanisms with automatically generated mechanisms. 

The Former USSR Republics as a Real-World Example... 

However, it should be emphasized that for sp-lCP-MS to work effectively at low concentrations, the speed of data acquisition and the response time of the ICP-MS quadrupole and detector electronics must be fast euough to capture the time-resolved nanoparticles pulses, which typically last only a few milliseconds or less. This is emphasized in Figure 20.9, which shows a real-world example of the time-resolved analysis of 30 nm gold particles by sp-ICP-MS. It can be seen that the gold nanoparticle has been fully resolved and characterized with 3-4 data points in <1 ms. For this kind of resolution, it is advantageous that the instrument measurement electronics are capable of very fast data acquisition rates, including dwell times that are as short as possible to capture the maximum number of data points within the transient event. It is also desirable that the quadrupole settling time is extremely short, so there... 

A BCI is a device that can decode human intent from brain activity alone in order to create an alternate communication channel for people with severe motor impairments. More explicitly, a BCI does not require the brain s normal output pathways of peripheral nerves and muscles to facilitate interaction with one s environment (Wolpaw et al., 2000, 2002). A real-world example of this would entail a quadriplegic subject controlling a cursor on a screen with signals derived from individual neurons recorded in the primary motor cortex without the need of overt motor activity. It is important to emphasize this point. A true BCI creates a completely new ouqtut pathway for the brain. 

Let us now discuss a real-world example of some synthetic peptides that exhibit distinct binding properties to semiconductor substrates. For this purpose, we are going to discuss the solution and adsorption behavior of synthetic 12-residue peptides, whose adhesion properties to surfaces of GaAs and Si crystals were the subject of extensive experiments [274-276,340]. 

The explosion aboard the USS Iowa represents a real-world example in which an organization, the US Navy, an organization quite familiar with the methodology of systems engineering, a well-defined management culture, and the tools of system safety, failed to build the bridge, resulting in the loss of forty-seven lives. 

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