A non-steroidal anti-inflammatory

Pd/P(t-Bu)., in the presence of Cy2NMe, is an unusually mild and versatile catalyst for Heck reactions of aryl chlorides (Tables 1 and 2) (as well as for room-temperature reactions of aryl bromides).21 22 23 Example A, the coupling of chlorobenzene with butyl methacrylate, illustrates the application of this method to the stereoselective synthesis of a trisubstituted olefin a-methylcinnamic acid derivatives are an important family of compounds that possess biological activity (e.g., hypolipidemic24 and antibiotic25) and serve as intermediates in the synthesis of pharmaceuticals (e.g., Sulindac, a non-steroidal anti-inflammatory drug26). Example B, the coupling of 4-chlorobenzonitrile with styrene, demonstrates that Pd/P(t-Bu). can catalyze the Heck reaction of activated aryl chlorides at room temperature. 

Khawaja, A.M., Liu, Y.C., and Rogers, D.F., Effect of fenspiride, a non-steroidal anti-inflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro, Pulm. Pharmacol. Then, 12, 363-368, 1999. 

Ficarra, R., Cutroneo, P., Aturki, Z., Tommasini, S., Calabro, M. L., Phan-Tan-Luu, R., Fanali, S., and Ficarra, P. (2002). An experimental design methodology applied to the enantioseparation of a non-steroidal anti-inflammatory drug candidate. J. Pharm. Biomed. Anal. 29, 989-997. 

Celecoxib, a non-steroidal anti-inflammatory drug, is a cyclo-oxygenase-2 selective inhibitor that is as effective as diclofenac and naproxen. It should be used for the shortest period required to control symptoms. Use is associated v/ith an increased risk of thrombotic events and the cyclo-oxygenase-2 selective inhibitors are contraindicated in cerebrovascular disease. Mobic is the proprietary preparation of meloxicam. 

Oruvail is a proprietary preparation of ketoprofen and Feldene is a proprietary preparation of piroxicam, both of which are non-steroidal antiinflammatory drugs Nootropil is a proprietary preparation of piracetam, which is not a non-steroidal anti-inflammatory drug. Nootropil is indicated as adjunctival treatment in cortical myoclonus. 

Concomitant administration of methotrexate and Voltarol, a proprietary preparation of diclofenac, a non-steroidal anti-inflammatory drug, may result in accumulation of methotrexate as its excretion is reduced. The use of diclofenac and diuretics such as bendroflumethiazide may increase the risk of nephrotoxicity. Concomitant use of alcohol and an angiotensin-converting enzyme inhibitor such as lisinopril (Zestril) may result in an enhanced hypotensive effect. Alcohol and the benzodiazepine diazepam (Valium) may result in enhanced sedation. 

Diclofenac is a non-steroidal anti-inflammatory drug. NSAIDs interact with both angiotensin-converting enzyme inhibitors, such as enalapril, and beta-adrenoceptor blockers, such as atenolol, resulting in antagonism to the hypotensive reaction, leading to a hypertensive reaction. NSAIDs interact with... 

Diclofenac (a non-steroidal anti-inflammatory drug) is marketed as Voltarol oral slow-release formulations. 

Rubefacients act by counter-irritation produced as a result of local vasodilation, resulting in a warm sensation that masks the pain. Counter-irritants should not be applied on broken skin or before or after taking a hot shower. Examples of counter-irritants include salicylates, nicotinates, capsicum, menthol and camphor. Ketoprofen is an example of a non-steroidal anti-inflammatory drug that is available as a topical preparation indicated in painful musculoskeletal conditions. 

Indometacin, which is a non-steroidal anti-inflammatory drug, inhibits the enzyme cyclo-oxygenase implicated in inflammatory reactions. Indometacin is more effective as an anti-inflammatory agent than ibuprofen and tends to have a higher side-effect profile, including headache, diarrhoea and gastrointestinal disturbances. Rectal administration reduces but does not prevent gastrointestinal tract disturbances. 

Naproxen is a non-steroidal anti-inflammatory agent classified as a propionic acid derivative. 

Flurbiprofen 622 (Froben , Cebutid ) is a non-steroidal anti-inflammatory whose structure makes it an ideal target for synthesis using a combination of the powerful deproto-nating ability of the superbases and the weakly directing effects of a fluoro or an aryl substituent (Scheme 243)" . 

Renal clearance is usually decreased. Renal blood flow in particular is often poised critically and the use of, for example, a non-steroidal anti-inflammatory drug may cause heart failure and/or renal failure in people with existing cardiac conditions or some preexisting degree of chronic renal failure. These non-selective inhibitors of the cyclo-oxygenase enzyme... 

Schwarzbeck A. Non-steroidal anti-inflammatory drugs and metformin. Lancet 1998 352(9130) 818. 

Indomethacin is a non-steroidal, anti-inflammatory agent with anti-pyretic and analgesic properties discovered and developed by the Merck Sharp and Dohme Research Laboratories(1). 

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID). It exhibits anti-inflammatory, analgesic and antipyretic activities. The mechanism of action is not completely understood but may be related to prostaglandin synthetase inhibition. 

The aim of this work is to investigate the adsorption and desorption of a pharmaceutical compound, taken as representative of a complex chemical molecule, on activated carbon. Nimesulide is a non steroidal anti-inflammatory drug currently used in defeating respiratory tract infections. 

Maria s medical notes show that she has mild rheumatoid arthritis (an autoimmune disease), the condition is not severe and her joint pain is well controlled by a non-steroidal anti-inflammatory drug (NSAID), taken twice a day. She is not trying to diet and apparently has a well-balanced food intake, but reports that she has recently had several minor stomach upsets and colds. A blood sample is taken for analysis, including a differential white blood cell count. 

Aspirin is a non-steroidal anti-inflammatory drug (NSAID) which is used to treat pain and, in low dosage, for the prophylaxis of coronary heart disease. It must be used with caution in asthmatic patients because of possible bronchoconstriction, and in large doses aspirin can adversely affect respiration by depressing the respiratory centre, leading to CO2 retention. Therefore it is not useful in COPD. 

Srimal, R.C., and Dhawan, B.N., Pharmacology of diferuloylmethane (curcumin), a non-steroidal anti-inflammatory agent, J. Pharm. Pharmacol, 25, 447, 1973. Satoskar, R.R., Shah, S.J., and Shenoy, S.G., Evaluation of antiinflammatory property of curcumin (diferuloylmethane) in patients with postoperative inflammation, Int. J. Clin. Pharmacol Then Toxicol, 24, 651, 1986. 

Contact dermatitis to a gel containing biphenylacetic acid, a non-steroidal anti-inflammatory agent, carbo-mer, and isopropanolamine has been reported (1). Patch tests showed a positive reaction to isopropanolamine (1% aqueous) on day 4. Patch-testing of 22 patients as controls showed one case of slight irritation. 

Another important substance in hemorrhoidal formulations is bufexamac, a non-steroidal anti-inflammatory drug that is a well-known sensitizer and sometimes elicits severe dermatitis (22). Bufexamac should therefore always be included in patch tests for anogenital dermatitis. 

Andrews R, Russell N. Aplastic anaemia associated with a non-steroidal anti-inflammatory drug relapse after exposure to another such drug. BMJ 1990 301(6742) 38. 

Sore throat treatments contain demulcents, antibacterials and local anaesthetics, and many products contain combinations of these. One sore throat lozenge contains flurbiprofen, a non-steroidal anti-inflammatory drug... 

Using a developed method, laser irradiation of colloidal mixtures of the three metals, these authors dispersed Au/Ag/Pd nanoparticles with average diameters 4.4 1.5 nm. These tri-metallic nanoparticles were assessed for activity in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone], a non-steroidal anti-inflammatory drug that has greater activity than aspirin and is comparable to naproxen and indomethacin. The 0.45-mol% Au/Ag/Pd was sufficient to catalyse the coupling of the 3-buten-2-ol... 

A typical example of an effective bioprecursor prodrug is given by the anti-inflammatory drug sulindac. Sulindac, di-5-fluoro-2-methyl-l-[p-(methylsulfinyl) benzylidene] indene-3 acetic acid is a non-steroidal anti-inflammatory agent having a broad spectrum of activity in animal models and in man. The two quantitatively significant biotransformations undergone by sulindac in laboratory species and... 

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