A-/J-peptides

Schnarr, N. A. Kennan, A. J. Peptide tic-tac-toe Heterotrimeric coiled-coil specificity from steric matching of multiple hydrophobic side chains. J. Am. 

Figure 7.20. Molecular structure of a (J-peptide fragment, containing chiral monomers.

Bella, J., Brodsky, B., Berman, H.M. Hydration structure of a collagen peptide. Structure 3 893-906, 1995. 

A. J. Tomlinson and S. Naylor, Enhanced performance membrane preconcentration-capillary electiophoiesis-mass spectiometry (mPC-CE-MS) in conjunction with transient isotachophoresis for analysis of peptide mixtures, J. High Resolut. Chromatogr. 18 384-386(1995). 

Figure 11.18 Schematic diagram of an in-line SPE unit for CE using (a) polyester wool frits to hold the sorbent, or (b) a paiticle-loaded membrane. Reprinted from Journal of Capillary Electrophoresis, 2, A. J. Tomlinson and S. Naylor, Enhanced performance membrane preconcenti ation-capillary electrophoresis-mass spectiometi y (mPC-CE-MS) in conjunction with ti ansient isotachophoresis for analysis of peptide mixtures, pp 225-233, 1995, with permission from ISC Teclmical Publications Inc.

Bruni, R., Taeusch, H.W., and Waring, A.J. Surfactant protein B Lipid interactions of synthetic peptides representing the amino-terminal amphipathic domain. Proc. Natl. Acad. Sci. USA 1991, 88, 7451-7455. 

Gordon, L.M., Lee, K.Y.C., Lipp, M.M., Zasadzinski, J.A., Walther, F.J., Sherman, M. A., and Waring, A.J. Conformational mapping of the N-terminal segment of surfactant protein B in lipid using C-13-enhanced Fourier transform infrared spectroscopy. J. Peptide Res. 

These studies conducted in solution and in the solid state revealed a common 3i4-helical fold stabilized by H-bonds closing 14-membered rings formed between NH and C=0 +2 (see Fig. 2.12A and C). It is noteworthy that the 3i4-helix of j -peptides with L-amino acid-derived chirality centers (Fig. 2.12 A) and the a-helix have opposite polarity and helicity. 

Fig. 2.38 sheet forming y-peptides. (A) Crystal structure of the two stranded antiparallel sheet formed by a,j -unsaturated y-dipeptide 152 with a-methyl substituted residues [208], Both intermolecular H-bonds are characterized by a N---0 distance of 2.84 A and an angle (N-H- -O) ofl54.2°. (B) Crystal structure of the infinite parallel sheet arrangement formed by vinylogous dipeptide 153 [208], Intermolecular H-bonds are characterized by a N -O distance of 2.88 A and 3.24 A and an... 

Hoen P.A. C., Prince P., Van der Bilt E., Valentijn A. R., Meeuwenoord N.J., Princen H., Bijsterbosch M.K., van der Marel G.A., van Boom J.H., van BerkelT.J.C. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepato-cytes. Bioconjug. Chem. 2002 13 295-302. 

Muratovska a., Lightowlers R. N., Taylor R.W., Turnbull D.M., Smith R.A. J., WiLCE J.A., Martin S.W., Murphy M.P. Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations implications for mitochondrial DNA replication, expression and disease. Nucleic Acids Res. 2001 29 1852-1863. 

Fig. 5.2 The a-helical peptide nucleic acid (aPNA) design concept. (Reprinted with permission from Garner P., Dey S., Huang Y.J. Am. Chem. Soc. 2000, 722, 2405 [51])...

Guzman F, Barberis S, Illanes A (2007) Peptide synthesis chemical or enzymatic. Electron J Biotechnol 10 279-314... 

Schneider JP, Pochan DJ, Ozbas B et al (2002) Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide. J Am Chem Soc 124 15030-15037... 

CHARLTON A J, BAXTER N J, KHAN M L, MOIR A J, HASLAM E, DAVIES A P, WILLIAMSON M P (2002) Polyphenol/peptide binding and precipitation. J Agric Food Chem. 50 1593-601. 

S., Grzesiek, S., litman, B. J., Bax, A. Measurement of dipolar couplings in a transdudn peptide fragment weakly bound to oriented photo-activated rhodopsin. f. Biomol. NMR 2000, 16, 121-125. 

Horuk R, Clayberger C, Krensky AM, et al. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem 2001 276 4199-4204. 

Luther M, Rusnak D, Sternbach DD, Mehrotra M, Peel M, Shampine L, Davis R, Robbins J, Patel IR, Kassel D, Burkhart W, Moyer M, Bradshaw T, Berman J. Peptide inhibitors of Src SH3-SH2-phosphoprotein interactions. J Biol Chem 1994 269 31711-31719. Also, for pTyr mimics see Ye B, Akamatsu M, Shoelson SE, Wolf G, Giorgetti-Peraldi S, Yan X, Roller PP, Burke TR Jr. L-0-(2-Malonyl)tyrosine a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. J Med Chem 1995 38 4270-4275. 

Since the discovery of the enkephalins in 1975 [11] a large number of endogenous opioid peptides have been detected in mammals, and at present three distinct families of opioid peptides are known (for a review, See Ref. 12). These are the enkephalins, the endorphins (a-, (J-, and y-), and the dynorphins and neoendorphins. The recently discovered endomor-phins [13] also may represent endogenous opioid peptides. Peptides with opioid activity have also been isolated from tryptic digests of milk casein... 

Montecucchi PC, de Castiglione R, Piani S, Gozzini L, Erspamer V. Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei. Int J Peptide Protein Res 1981 17 275-283. 

Marsden BJ, Nguyen TM-D, Schiller PW. Spontaneous degradation via diketopiperazine formation of peptides containing a tetrahydroisoquinoline-3-carboxylic acid residue in the 2-position of the peptide sequence. Int J Peptide Protein Res 1993 41 313-316. 

Fraser PE, McLachlan DR, Surewicz WK, Mizzen CA, Snow AD, Nguyen JT, Kirschner DA. Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues. J Mol Biol 1994 244 64-73. 

Garren, K. W., Pyter, R. A., Aqueous solubility properties of a dibasic peptide-like compound, Int. J. Pharm. 63, 167-172 (1990). 

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