Piper methysticum

This next example involves the well-known plant kawa. A psychoactive beverage made from the roots of this plant is used widely in the islands of the southwestern Pacific Ocean either for ritualistic or routine consumption. Kava is the common name for Piper methysticum Forst. f. from which several compounds responsible for the pharmacological activity have been isolated and identified. Representative structures of the family of styrylpyrones, commonly called kavalactones, are given in Fig. 6.6. The compounds are based upon a carbon skeleton consisting of a styryl function (C C ) attached to a six-membered lactone ring. The fundamental compound, kawain, is shown as structure [547]. Structural variants include... [Pg.259]

Shore, J. S. and Christ, C. M. 1992. Variation in cyanogenesis within and among populations and species ofTumem section Canaligerae (Tumeraceae). Biochem. Syst. Ecol. 20 9-15. Simeoni, P. and Lehot, V. 2002. Identification of factors determining kavalactone content and chemotype in Kava (Piper methysticum Forst. f). Biochem. Syst. Ecol. 30 413 24. [Pg.329]

Phenolics Piper methysticum SiOj UV 254 and Effect on cyclooxygenaze enzyme 85... [Pg.266]

Avdeef, A., Strafford, M., Block, E., Balogh, M. P., Chambliss, W., Khan, I. Drug absorption in vitro model filter-immobilized artifidal membranes 2. Studies of the permeability properties of lactones in Piper methysticum Forst. Eur.J. Pharm. Sci. 2001, 14, 271-280. [Pg.50]

A classic example of a medicinal plant of Asia and the Pacific with GABAergic properties is Piper methysticum Forst. (Kava, British Pharmaceutical Codex, 1934), or kava-kava, the rhizomes of which have been used since a very early period of time by Polynesians to allay anxiety and reduce fatigue. Kava has been marketed in Europe to treat sleep disorders and anxiety. The beverage normally induces a form of euphoria, described as a happy state of complete comfort and peace, with ease of conversation... [Pg.102]

Klohs MW, Keller F, Williams RE, Toekes MI, Cronheim GE. A chemical and pharmacological investigation of Piper methysticum Forst. J Med Pharm Chem 1959 1 95-103. [Pg.159]

I. Khan. Drug absorption in vitro model filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst, Eur. [Pg.89]

Piper methysticum Forst is a bush tree from Polynesia, known under the local name of kawa-kawa its roots are used in the preparation of an inebriating social beverage called kava, the active principles of which are not alkaloids. Two alkaloids were isolated from the root 1-cinnamoylpyrrolidine (138) and 1 -(m-methoxycinnamoyl)pyrrolidine (139) (208). Their structures were determined by spectroscopic means as well as by total synthesis. [Pg.324]

Backhauss C, Kriegistein J. (1992). Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol. 215(2-3) 265-69. [Pg.494]

Bhate H, Gerster G, Gracza E. (1989). Orale pramedikation mit Zubereitungen aus Piper methysticum bei operativen Eingriffen in Epiduralanasthesie. Erfahrungsheilkunde. 6 339-45. [Pg.494]

Gleitz J, Beile A, Wilkens P, Ameri A, Peters T. (1997). Antithrombotic action of the kava pyrone (+)-kavain prepared from Piper methysticum on human platelets. Planta Med. 63(1) 27-30. [Pg.496]

Jamieson DD, Duffield PH, Cheng D, Duffield AM. (1989). Comparison of the central nervous system activity of the aqueous and lipid extract of kava (Piper methysticum). Arch Int Pharmacodyn Ther. Sept.-Oct. 301 66-80. [Pg.497]

Jussofie A, Schmiz A, Hiemke C. (1994). Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology (Berlin). 116(4) 469-74. [Pg.497]

Munte TF, Heinze HJ, Matzke M, Steitz J. (1993). Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. Neuropsychobiology. 27(1) 46-53. [Pg.500]

Uebelhack R, Franke L, Schewe FIJ. (1998). Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 31(5) 187-92. [Pg.502]

Kava (Piper methysticum) Relieves nervousness and protects against stress... [Pg.42]

Lechmann E, Kinzier E, Friedemann J. Efficacy of a special kava extract (Piper methysticum) in patients with states of anxiety, tension and excitedness of non-mental origin. A double-blind placebo-controlled study of four weeks treatment. Phytomedicine 1996 2 113-119. [Pg.250]

Kava Piper methysticum) 03/26/2002 Kava is associated with liver-related injury including hepatitis, cirrhosis, and liver failure... [Pg.15]

Kava Piper methysticum) All products containing kava 12/19/2001 Kava-containing products have been implicated in serious liver toxicity... [Pg.15]

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