X-protein

Coagulation Factors II, III, VII, IX, X, XI, and Xlla fragments, thrombin, and plasmin are classified as serine proteases because each possesses a serine residue with neighboring histidine and asparagine residues at its enzymatically active site (Table 3). Factors II, VII, IX, and X, Protein C, Protein S, and Protein Z are dependent on the presence of vitamin K [84-80-0] for their formation as biologically functionally active procoagulant glycoproteins. 

Figure 2. CM-cellulose chromatography of pectolytic enzymes. The activity peaks of the flow-through of a DEAE-cellulose chromatography was applied to a CM-cellulose column. The column was eluted with a NaCl (0-0.5M) continuous gradient at a flow rate of 34 ml/h. 10 ml fractions were collected and assayed for pectolytic activities Symbols (0) pectate lyase ( ) polygalacturonase (reducing sugar-releasing activity) (x) protein. Other details in Methods.

Protein-[Fe24+02]4+ - —x Protein-[Fe26+022 ]4+ (peroxo intermediate) (3)... 

Significantly more phosphorus was excreted in the feces when 1.2% calcium and 1.2% phosphorus diets were fed with either egg white (317 mg) or soy (303 mg), than when any of the other rations were fed. Orthogonal contrast analysis indicated that statistically significant sources of these differences included ration phosphorus level (P <0.001), calcium level (P< 0.0001), and calcium level x protein source (P< 0.0461). The degree of effectiveness of increasing phosphorus excretion with increased ration level of calcium was greater in egg white fed animals than in soy fed animals. 

In model-1 (Fig. 1), which provides the mechanism of AR-JP, cumulative increases of a putative parkin substrate(s), provisionally termed X(s), which has yet to be identified, cause selective neuronal death. In this model, the target X protein is simply considered as a factor whose accumulation directly mediates death of dopaminergic neurons i.e., abnormal accumulation of X forcibly evokes cell death. To explain that genetic defect of the parkin gene causes specifically dopaminergic neuronal... 

Fe proteins in nitrogenase, 38 252-254 photosystem I reaction center X proteins, 38 251-252... 

Rieke proteins, 47 337, 347-355 superoxide dismutases and, 45 129 Photosynthetic bacteria, 2[4Fe-4S] and [4Fe-4S] [3Fe-4S] ferredoxins, 38 255-257 Photosystem 1, 38 303-304 Pa/Fb proteins, 38 262-263 reaction center X proteins, single [4Fe-4S] ferredoxins cluster bridging two subunits, 38 251-252 Photosystem II, 46 328 interatomic separations, 33 228 mechanisms for water oxidation, 33 244-247... 

X-Protein. Amyloid p i 42 peptide and r-protein have a clinical significance as early diagnostic markers in Alzheimer s disease (AD), and its evaluation is mandatory for efficient treatment. The mean levels of A/3i 42 and r-protein in CSF were significantly reduced (with high specificity and sensitivity) in patients in comparison to normal findings (M6). 

One theory of the pathogenesis of Alzheimer s disease proposes that increased production or decreased secretion of the Ap peptides leads to accumulation of these peptides. A second theory proposes that an abnormal x-protein causes the formation of intracellular neurofibrillary tangles. x-Proteins are important in the maintenance of cytoskeleton function and axonal transport of proteins. Another theory is that Ap accumulation is a precipitating factor that is followed by the development of the x-enriched tangles in the dying neurons. 

Doxycydine (Adoxa, Periostal-, Oracea, Vibramycin, Vibra-Tabs) [Anribiotic/Tetracycline] Uses Broad-spectrum antibiotic acne vulgaris, uncomplicated GC, Chlamydia sp, PID, Lyme Dz, skin Infxns, anthrax, malaria prophylaxis Action Tetracycline bacteriostatic X- protein synth Dose Adults. 100 mg PO ql2h on 1st d, then 100 mg PO daily bid or 100 mg IV ql2h acne daily dosing, Chlamydia 7d, Lyme Dz 14—21 d, PID 14 d Peds >8 y 5 mg/kg/24 h PO, to a max of 200 mg/d - daily-bid Caution [D, +] Hepatic impair Contra Children <8 y, severe hepatic dysfxn Disp Tabs, caps, syrup, susp, inj SE D, GI disturbance, photosens Interactions T Effects OF digoxin, warfarin 1 effects W/ antacids, Fe, barbiturates, carbamazepine, phenytoins, food 4-effects OF penicillins EMS Monitor for signs of electrolyte disturbances and hypovolemia d/t D monitor for S/Sxs of super Infxn T risk of photosensitivity Rxns antibiotic of choice for the Tx and prophylaxis of anthrax exposure expired tetracyclines have been known to cause nephrotox OD May cause adverse GI effects symptomatic and supportive... 

Infection by human hepatitis B or C virus is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma (HCC) (Brechot, et al., 2000, Colombo, et al., 2003). Although they act via different mechanisms, both viruses directly influence the control of Ca2+ homeostasis in human hepatocytes. One of the proteins encoded by the HBV genome, the hepatitis virus X protein... 

Chami, M., Ferrari, D., Nicotera, P., Paterlini-Brechot, P. and Rizzuto, R., 2003, Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein. J Biol Chem 278, 31745-55. 

Lee, Y. I., Kang-Park, S. and Do, S. I., 2001, The hepatitis B virus-X protein activates a phosphatidyli-nositol 3-kinase-dependent survival signaling cascade. J Biol Chem 276, 16969-77. 

Murakami, S., 2001, Hepatitis B virus X protein a multifunctional viral regulator. J Gastroenterol 36, 651-60. 

Bennett, P., Craig, R., Starr, R., and Offer, G. (1986). The ultrastructural location of C-protein, X-protein and H-protein in rabbit muscle. J. Muscle Res. Cell Motil. 7, 550-567. 

Azocarmine B was originally used by Turba and Enenkel (T4) as a saturated solution and is prepared in a mixture of 50 % methanol, 10 % glacial acetic acid, and 40 % water. Rinsing is done with methanol and later on with 1 % acetic acid. The wavelength needed for colorimetry is 520m[x. Protein factors again vary widely 1 (T4), 1.35 (M3), 1.5 (V2), 1.6 (E4, E5), 1.8 (P18). 

Reduces synthesis of clotting factors (II, VII, IX, and X, protein C and S) Targeted specificity for thrombin direct competitive and reversible inhibition of both free and clot-bound thrombin... 

Shikata E, leiri I, Ishiguru S, et al. Association of pharmacokinetics (CYP2C9) and pharmacodynamics (factors II, VII, IX, and X protein S and C and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity. Blood 2004 103 2630-2635. 

Dunn-Coleman NS, Diaz-Torres M, Chase MW, Trimbur D (1998) Method for the recombinant production of 1,3-propanediol using protein x, protein 1, protein 2, and protein 3 for dehydratase reactivation. WO 98/21341... 

Ishizuka A, Siomi M, Siomi H A Drosophila fragile X protein interacts with components of RNAj and ribosomal proteins. Genes Dev 16 2497-2508, 2002. 

Morales J, Hiesinger PR, Schroeder AJ, et al. Drosophila fragile X protein, DFXR, regulates... 

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