X-link inhibitor of apoptosis protein

Tun C, Guo W, Nguyen H, Yun B, Libby RT, Morrison RS, Garden GA (2007) Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis. J Neurochem 102 1206-1219... 

Suzuki, Y., Y. Nakabayashi, and R. Takahashi, Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes protea-... 

Perrelet D, Perrin FE, Liston P, Korneluk RG, MacKenzie A, Ferrer-Alcon M, Kato AC (2004) Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XlAP-assodated factor 1. J Neurosci 24 3777-3785... 

Proteins containing these domains have been shown to inhibit caspases. At least 8 members of the mammahan family of lAP proteins containing two to three copies of the BIR domain have been identified. These BIR domains may function differently in the inhibition of the caspases. The third BIR repeat, BIR3, of the X-linked protein, X-linked inhibitor of apoptosis protein (XIAP) binds to monomeric initiator caspase-9 to form a heterodimer and thus prevents caspase-9 from forming its functional dimer, resulting in loss of enzymatic activity. ... 

Huang Y, et al. Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein 120. (XIAP)-mediated caspase inhibition by Smac. J. Biol. Chem. 2003 278 49517-49522. 

Splan KE, Allen IE, McLendon GL. Biochemical basis for enhanced binding of Peptide dimers to x-linked inhibitor of apoptosis protein. Biochemistry 2007 46 11938-11944. 

TER TMEV TMT TN toll-like receptor Theiler s mouse encephalomyelids virus dime thy Idn terminal nuclei X-ALD XIAP X-adrenoleukody s dophy X-linked inhibitor of apoptosis protein... 

Sun H, Stuckey JA, Nikolovska-Coleska Z et al (2008) Structure-based design, synthesis, evaluation and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP). J Med Chem 51 7169-7180... 

Nikolovska-Coleska Z, Meagher JL, Jiang S et al (2008) Interaction of a cyclic, bivalent Smac mimetic with the X-linked inhibitor of apoptosis protein. Biochemistry 47 9811-9824... 

Suzuki Y, Nakabayashi Y, Nakata K et al (2001) X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J Biol Chem 276(29) 27058-27063... 

Sasaki H, Sheng Y, Kotsuji F et al (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60(20) 5659-5666... 

Cummings, J., Ward, T.H., LaCasse, E., Lefebvre, C., St Jean, M., Durkin, J., Ranson, M., and Dive, C. (2005) Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X linked inhibitor of apoptosis protein XIAP. British Journal of Cancer, 92, 532 538. 

Yamagiwa, Y., Marienfeld, C., Meng, F., Holcik, M., and Patel, T. Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6 A novel mechanism of tumor cell survival. Cancer Res 64, 1293-1298 (2004). 

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