WWW Bioinformatics Resources

University of Hong Kong and University of California, Irvine, California, U.S.A. 

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The Kyoto Encyclopedia of Genes and Genomes (KEGG) is a bioinformatics resource for genome information, http //www.genome.ad.jp/kegg/. 

Resource site for biotechnology—Molecular biology, bioinformatics, biophysics, and biochemistry—A well-organized web site http //WWW.ahpcc. unm. edu/ aroberts/... 

ExPASy (Expert Protein Analysis System, www.expasy.ch) or the National Centre for Biotechnology Information (NCBI, www.ncbi.nlm.gov) websites. Both websites provide bioinformatics tools, links to sequence databases and extensive bibliographic resources. As an example of the wealth of information available on individual enzymes, at the time of writing a search based on nitrilase in the Entrez protein section of NCBI will recover more than 10000 references to nitrilase enzyme amino acid sequences. These can be rapidly screened online by organism, and the individual entries will have links to amino acid and gene sequence, relevant literature and information on protein features (such as conserved domains). 

U.K. HGMP Resource Center—MRC Rosalind Franklin Center for Genomics Research Bioinformatics (http //www.hgmp.mrc.ac.uk/Bioinformatics/)... 

University of Manchester Bioinformatics Education and Research (UMBER) Site (http //www.umber.embnet.org/ resources)... 

Bioinformatics and biotechnology law resources have been compiled to deal with this other side of research in some useful sites, e.g., University of W ashing-ton School of Law site (http //lib.law.washington.edu/ref/biotech.htm) and a commercial site (http //www.denniskennedy.com/bioinformaticslaw.htm). 

European allergy information resource center. European Bioinformatics Institute—http //www.ebi.ac.uk/... 

Universal Protein Knowledgebase (UniProt). European Bioinformatics Institute (EBI), Swiss Institute of Bioinformatics (SIB), Protein Information Resource (PIR), Georgetown Univ. URL http //www.uniprot.org. Central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR. A central access point for extensive curated protein information, including function, classification, and cross-reference. 

In this paper we describe the basic design of a microarray gene expression database to help microarray users and their informatics teams set up their information services. The first version of the microarray database object model ArrayExpress, which is described here, was developed at the European Bioinformatics Institute (EBI) in collaboration with the German Cancer Research Centre (DKFZ) and posted on the Internet in November, 1999 (see (http //www.ebi.ac.uk/arrayexpress)). A relational database implementation maxd based on the ArrayExpress object model was conducted at the University of Manchester (http //bioinf.man.ac.uk/microarray/resources.html) and is widely used for microarray laboratory informatics support. 

A considerable amount of information about protein sequences and architecture is available on the World Wide Web. One of the most important resources is the Protein Data Bank operated under the auspices of the Research Gollaboratory for Structural Bioinformatics (RGSB). Its URL is http //www.rcsb.org/pdb. This... 

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