Warfarin adverse reactions

The term pasaon flower is used to denote many of the approximately 400 species of the herb. F saon flower has been used in medicine to treat pain, anxiety, and insomnia. Some herbalists use the herb to treat symptoms of parkinsonism. F saon flower is often used in combination with other herbs , such a valerian, chamomile, and hops, for promoting relaxation, rest and sleep. Although no adverse reactions have been reported, large doses may cause CNS depression. The use of passion flower is contraindicated in pregnancy and in patientstaking the monoamine oxidase inhibitors (MAOIs). Fission flower contains coumarin, and the risk of bleeding may be increased when used in patientstaking warfarin and pasaon flower. 

Discuss the uses, general drug actions, adverse reactions, contraindications, precautions, and interactions of warfarin, heparin preparations, and the thrombolytic drugs. 

The principal adverse reaction associated with warfarin is bleeding, which may range from very mild to severe. Bleeding may be seen in many areas of the body, such as the bladder, bowel, stomach, uterus, and mucous membranes. Other adverse reactions are rare but may include nausea, vomiting, alopecia (loss of hair), urticaria (severe skin rash), abdominal cramping, diarrhea, rash, hepatitis (inflammation of the liver), jaundice (yellowish discoloration of the skin and mucous membranes), and blood dyscrasias (disorders). 

In summary, the adverse effects associated with the quinolones appear presently to be mild to moderate in severity and reversible upon discontinuation of therapy. Severe systemic adverse reactions are rare [62], It is suggested that the use of these agents should be avoided, as far as possible, in children and pregnant women and that caution be used in their administration to patients with a seizure disorder or those taking theophylline or warfarin [62]. Articles suggesting the appropriate clinical usage for these important antibacterials have appeared [64],... 

Adverse reactions at therapeutic doses are usually minimal and transient. With long-term use, initial side effects usually disappear. The following reactions were reported in 2 heart valve replacement trials comparing dipyridamole and warfarin therapy to either warfarin alone or warfarin and placebo dizziness, abdominal distress, headache, and rash. 

The principal adverse reaction to warfarin is hemorrhage. Prolonged therapy with the coumarin-type anticoagulants is relatively free of untoward effects. Bleeding may be observable (e.g., skin, mucous membranes) or occult (e.g., gastrointestinal, renal, cerebral, hepatic, uterine, or pulmonary). Rarer untoward effects include diarrhea, small intestine necrosis, urticaria, alopecia, skin necrosis, purple toes, and dermatitis. 

Jolson HM, Tanner LA, Green L, Grasela TH Jr. Adverse reaction reporting of interaction between warfarin and fluoroquinolones. Arch Intern Med 1991 151(5) 1003-4. 

Soybean oil is widely used intramuscularly as a drug vehicle or as a component of emulsions used in parenteral nutrition regimens it is also consumed as an edible oil. Generally, soybean oil is regarded as an essentially nontoxic and nonirritant material. However, serious adverse reactions to soybean oil emulsions administered parenterally have been reported. These include cases of hypersensitivity, CNS reactions, " and fat embolism. " Interference with the anticoagulant effect of warfarin has also been reported. ... 

Krynetskiy E, McDormell P. Building individualized medicine prevention of adverse reactions to warfarin therapy. J Pharmacol Exp Ther 2007 322 427-34. 

The most common adverse reactions in patients receiving erlotinib were diarrhea and rash. Serious interstitial lung disease also has been reported. Other adverse effects include elevated liver enzymes and bleeding, especially in patients receiving warfarin. Coadministration of CYP3A4 inhibitors is expected to increase toxicity to erlotinib. 

Warfarin LESS-DILI concern Adverse reactions NEG POS NEG... 

Adverse reactions to somatostatin analogues have been extensively reported. The asymptomatic effects have been reviewed [23, 34 ]. There are asymptomatic gallstones in 20-40, bradycardia in up to 25%, and conduction abnormalities in 10%. Somatostatin analogues may alter the absorption of other drugs, especially oral hypoglycemic agents, p blockers, calcium channel blockers, and dclosporin, while effects on CYP isoenzymes may alter concentrations of quinidine, terfenadine, and warfarin. Somatostatin analogues... 

Dobutamine stress echocardiography is a generally well-tolerated study to evaluate patients with suspected coronary artery disease. Rare but life-threatening complications of this study have been well described. Severe hypertensive responses are a known but uncommon adverse reaction to dobutamine infusion. A case of intracranial haemorrhage in the setting of severe hypertension as a complication of dobutamine stress echocardiography was reported. The patient was on systemic anticoagulation with warfarin for a prosthetic mitral valve and had... 

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