Wafer capsules

Sales of Ca supplements alone were 875 million in the United States in 2002, and comprised 60% of all mineral supplement sales (Anonymous, 2004). In 2004, sales of Ca supplements increased by 9.3% (Uhland et ah, 2004), possibly to some extent in response to the Surgeon General s report on bone health that was issued that year. More recently in 2006, it was projected that dietary supplement sales in the United States would approach 5 billion (Anonymous, 2006). While Ca derived from a balanced diet is preferable, Ca supplements are a popular noncaloric alternative for increasing daily Ca intake. There are a vast number of oral Ca supplements available in the market place in the form of capsules, tablets, chewable tablets, effervescent tablets, liquids, powders, suspensions, wafers, and granules. However, not all Ca salts are equally soluble or bioavailable and the dose of Ca on the label of a supplement may not necessarily be reflective of the relative amount of available Ca once consumed. Furthermore, the same Ca salt may be more or less bioavailable depending on the production process and materials used to manufacture the supplement. 

Constipation, irritable bowel syndrome PO Akrt3.4gpowderequals 1 rounded tsp, 1 packet,or Iwafer. 2-5 capsules/dose l-3timesaday. 1-2 tsp granules l-2timesaday. 1 rounded tsp or 1 tbsp of powder 1-3 times a day. 2 wafers 1-3 times a day. 

Pool Technique. Resin beads are the most frequently used formulation of insoluble support for solid-phase organic synthesis. However, the yield from one typical bead (100 jam) is only about lOOpmol. The need for substantially higher yield from one unit of solid phase triggered the development of different formulations of solid support. Two different scenarios were followed compartmentalization of resin beads (T-bags, wafers, Kans, capsules, and resin plugs) and development of modular solid support (SynPhase Lanterns, rods). 

Wafers and Capsules. Another solution of compartmentalization of resin beads into permeable containers was reported by Beattie and Frost, who invented porous wafers that housed insoluble supports for the multiple solid-phase synthesis of oligonucleotides and peptides. The porous wafer was made from a Teflon ring covered on both sides by a porous Teflon membrane to form a cylindrical permeable container. The use of wafers was reduced to practice in a specialized column-based oligonucleotide synthesizer. ... 

Resin capsules represent an alternative solution to Teflon wafers designed for multiple/ combinatorial solid-phase organic synthesis. The capsules consist of a polyethylene ring sealed with peek mesh on both sides (Figure 3.10). The reaction vessel consists of a sealed Teflon tube, in which washing resin beads can be carried out in a continuous flow manner. 

Chemical History of the Resin Formulations. The most straightforward solution to track the chemical history during split-and-pool synthesis is labeling paper disks," T-bags, wafers, or capsules with an alphanumeric code... 

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