SynPhase™ Lanterns

Fig. 7.10 Polymer-supported scavengers polystyrene-bound diamine (top left), silica-based diamine (top right), Stratosphere Plugs (bottom left), and Synphase Lanterns (bottom right).

This diffusion-filtered approach has been extended in application to macroscopic supports, specifically a Synphase lantern.77 The advantage of the diffusion-filtered experiment was extended to suppression of the macroscopic support signals, not just those of the protonated solvents. Although, the lanterns required some modification to fit in the MAS rotors, it is proposed that manufacturers account for this size restriction in future formats of these supports. 

A Review of Solid-Phase Organic Synthesis on SynPhase Lanterns and SynPhase Crowns... 

Mimotopes has been involved in the development, use, and commercialization of radiation-grafted polymer surfaces for multiple parallel synthesis since the late 1980s.10-12 Although other workers have reported the use of radiation-graft polymers in solid-phase synthesis,13,14 as far as we are aware, the graft polymer devices manufactured and sold by Mimotopes (SynPhase Crowns, SynPhase Lanterns) are the only current commercial products of this type. These products are presented in Fig. 1. The SynPhase Lanterns are the current design for small molecule synthesis. The initial... 

SynPhase Crown SynPhase Lantern Fig. 3. SynPhase Lantern and SynPhase Crown symbols used in this chapter. 

Polystyrene grafted SynPhase Lanterns were used by Makino et al.33 at Ajinomoto to synthesize a diverse quinazoline-2-thioxo-4-one library. Lanterns functionalized with long-chain HMP (hydroxymethylphenoxyvaleric amide) linker were coupled with nitrophenols by the action of DIC/ HOAt/DMAP to give nitrobenzenes 14 (Scheme 6). The nitro group was... 

Series of ureas 96, thioureas 97, carbamates 98, and semicarbazides 99 were prepared on resin or SynPhase Lanterns by Phoon and Sim56 from Singapore s Institute of Molecular and Cell Biology. These derivatives... 

Bromo-Wang polystyrene resin or Bromo-Wang SynPhase Lantern... 

Fig. 1. Chiron Mimotopes Crowns. (A) Crown (B) stem (C) carved stem with hole (D) support unit (E) full-length stem labeling the head of the string. The scratches represent the string number (F) half stem that marks the tail of the string (G) Mimotopes SynPhase Lantern with stem.

The Encore synthesizer has been designed to integrate the process of handling of solid-phase particles in combinatorial synthesis. The current version of the synthesizer enables synthesis in batches of up to 960 compounds on SynPhase Lanterns. The Encore synthesizer facilitates the sorting of Lanterns into sequences (necklace coding) and the plating of the Lanterns after completion of the synthesis for final release of compounds from Lanterns. The Encore synthesizer consists of the following five tools. 

Combinatorial chemistry has moved from specially centralized laboratories, often equipped with multimillion-dollar robots, onto the bench of individual medicinal chemists. This change in direction requires the availability of personal chemistry tools that are simple to operate, easy to arrange in the laboratory, and reasonably priced. Such instruments are now available for the effective synthesis of combinatorial libraries. The Encore synthesizer represents a simple and efficient personal chemistry tool that allows the execution of directed split-and-pool combinatorial synthesis. The current version of the Encore synthesizer is designed for solid-phase synthesis on SynPhase Lanterns however, it can be modified for synthesis on alternative solid supports such as resin plugs from Polymer Laboratories (e.g., StratoSpheres Plugs). 

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