Aspergillosis allergic bronchopulmonary

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Dreschlera (25), can cause similar disease. Therefore, the terms allergic bronchopulmonary mycoses (ABPM), allergic bronchopulmonary fungosis (ABPF), allergic bronchopulmonary candidiasis (ABPC), and allergic bronchopulmonary helminthosporosis (ABPH) have been used to describe illnesses similar to ABPA (26,27). 

ABPA was first described in 1936 in a young boy with a family history of atopy, who had atopic eczema followed by asthma, eosinophilia, and proximal bronchiectasis (28). Five years later, similar patients with a positive family history were recognized (29). However, it was not until 1952 (30), when the offending organism, A. fumigatus, responsible for ABPA was recognized in England. The first case of ABPA in the United States was identified in 1968 (31). Since then, many reports of ABPA have appeared in the literature (5,27,32-34). 

ABPA occurs in 1-2% of patients with asthma (10,27) and in up to 10% (7-35%) of patients with cystic fibrosis (10,27,35). It is characterized by intermittent or continuous colonization of the bronchi by the fungus in conjunction with the unique immunological reaction and pathophysiogical findings. The conidia and hyphae have receptors for anti-Af IgE (26,36). 

The immunopathogenesis of ABPA is still incompletely understood. The clinical manifestations of disease may result from complex interactions between the host and the fungal organism and the host s genetically determined immune response. Several host factors, including the humoral response with specific IgE- 

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ABPA = Allergic bronchopulmonary aspergillosis CMC = chronic mucocutaneus candidiasis. ... 

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Molecular Cloning of Aspergillus fumigatus Allergens and Their Role in Allergic Bronchopulmonary Aspergillosis... 

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Leser C, Karrfifrrran HF, Virchow C, Merrz G Specific semm irrrmunopattems in clinical phases of allergic bronchopulmonary aspergillosis. J Allergy Clin Irrrmunol 1992 90 589-599. 

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Crameri R, Hemmann S, Ismail C, Menz G, Blaser K Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis. Int Irrrmunol 1998 10 1211—1216. 

Basisch JE, Graves TS, Baz MN, Scanlon G, Hoffman R, Patterson R, et al Allergic bronchopulmonary aspergillosis in corticoid-dependent asthmatics. J Allergy Clin Immunol 1981 68 98-102. 

Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE Clinical and immunological criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 1977 86 405-414. 

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