Vitamin palmitate beadlets

The stability of solid dosage forms is usually very susceptible to the moisture content of the atmosphere in the container in which they are stored (see section 4.4.3) A linear relationship between log k and the water vapour pressure for vitamin A palmitate beadlets in sugar-coated tablets has been found. Similarly, a linear relationship between the logarithm of the rate constant for the decomposition of nitrazepam in the solid state and the relative humidity has been established (Fig. 4.f9). The need for consideration of the effect of moisture on stability has been stressed by Carstensen, who stated that stability programmes should always include samples that have been artificially stressed by addition of moisture. One purpose of a stability programme should be to define the stability of the dosage form as a function of moisture content. 

Palmabeads. [Hoffmann-La Roche] Dry vitamin A palmitate beadlets. 

Foods are supplemented with vitamin A in the form of standardized preparations of synthetic fatty acyl esters, nowadays chiefly retinyl palmitate. The preparations are available commercially as either dilutions in high-quality vegetable oils containing added vitamin E as an antioxidant or as dry, stabilized beadlets in which the vitamin A is dispersed in a solid matrix of gelatin and sucrose or gum acacia and sucrose. The oily preparations are used to supplement fat-based foods such as margarines the dry preparations are used in dried food products such as milk powder, infant formulas, and dietetic foods (24). 

Vitamin A with its five conjugated double bonds oxidizes to 5,8-epoxides (15) with subsequent loss of UV absorption at 325 nm. Thus, vitamin A was studied with the addition of various antioxidants (Table XI) in open bottles in thin layers. Although EMQ was the best, it is limited to use in vitamin A for animal feeds. AP activity was not great, but when added to a mixture of tocopherol, BHT, and diethanolamide, AP gave excellent protection. Klaui (16) has shown stability of vitamin A palmitate with tocopherol, AP, and an amine equal to 1300 h, compared to a control equal to 100 h. However, the antioxidants in the dry market form (beadlets) protect the vitamin A in the beadlets as well as the end use of the product. For example, spray-dried vitamin A can be pro-... 

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