Vitamin D3 receptor

The retinoid X receptor (RXR) is a nuclear receptor that binds and is activated by certain endogenous retinoids, such as 9-cis-retinoic acid. RXR is the obligatory heterodimerization partner for a large number of nonclassic steroid nuclear receptors, such as thyroid hoimone receptor, vitamin D3 receptor, peroxisome proliferator-activated receptor and pregnane X receptor. [Pg.1071]

TF transcription factor, R receptor, Fur ferric uptake regulation protein, NF-kB nuclear factor-kB, AP-1 activator protein-1, Egr-1 early growth response-1, VDR la,25-dihydroxy-vitamin D3 receptor, RXR retinoid X receptor, PPARy peroxisome proliferator-activated receptor y NFAT nuclear factor of activated T-cells, HSF heat shock factor, p53 tumor suppressor p53, HIF-1 hypoxia inducible factor-1. ... [Pg.331]

Vitamin D3 receptor (VDR) Heterodimer 1,25-Dihydroxy vitamin D3 Direct repeat... [Pg.191]

In Table 11.2 the properties of two families of nuclear receptors, A and B, are compared. To family A belong the steroid hormone receptors and to family B, the non-steroidal receptors,25 the thyroid hormone receptors, the retinoic acid receptors, the vitamin D3 receptor, the peroxysome proliferator activating receptor, and several orphan receptors. [Pg.200]

B Thyroid hormone receptor, THR All-trans retinoic acid receptor, RAR Vitamin D3 receptor, VDR 9-c/s retinoic acid receptor, RXR, Peroxysome proliferator activating receptor, PPAR Orphan receptors Short A/B domains do not associate with chaperones. Unliganded receptors bind to DNA... [Pg.201]

Milde, P Merke, J, Ritz, E, Haussler, M, andRauterberg, E. (1989) Immunohis-tochemical detection of 1,25-dihydroxy vitamin D3 receptors and estrogen receptors by monoclonal antibodies comparison of four immunoperoxidase methods. J. Histochem. Cytochem 37, 1609-1617... [Pg.193]

Masood, R. et al. (2000) Kaposi sarcoma is a therapeutic target for vitamin D3 receptor agonist. Blood, 96, 3188-3194. Welsh, J. et al. (2003) Vitamin D-3 receptor as a target for breast cancer prevention. The Journal of Nutrition, 133 (7 Suppl), 2425-2433 S. [Pg.355]

Bury, Y. et al. (2001) Molecular evaluation of vitamin D3 receptor agonists designed for topical treatment of skin diseases. The Journal of Investigative Dermatology, 116, 785-792. [Pg.363]

A FIGURE 11-42 Consensus sequences of DNA response elements that bind three nuclear receptors. The response elements for the glucocorticoid receptor (GRE) and estrogen receptor (ERE) contain inverted repeats that bind these homodimeric proteins. The response elements for heterodimeric receptors contain a common direct repeat separated by three to five base pairs, for the vitamin D3 receptor (VDRE), thyroid hormone receptor (TRE), and retinoic acid receptor (RARE). The repeat sequences are indicated by red arrows. [See K. Umesono etal., 1991, Ce//65 1255, and A. M. Naaretal., 1991, Ce//65 1267]... [Pg.483]

The DRIP (Vitamin D3 receptor [VDR] interacting proteins) complex was purified using a VDR ligand-binding domain affinity matrix (Rachez et al., 1998). DRIP is needed for full transcriptional activity of VDR on naked DNA templates in vitro. Another complex, ARC (activator-recruited cofactor), was identified as a complex that enhances transcription activation by SREBP-la, VP16, and the p65 subunit of NF-kappaB using chromatin-assembled DNA templates (Naar et al., 1999). Characterization of the subunits of DRIP and ARC showed that the two complexes are highly related—if not identical—to each other and also to the TRAP/SMCC complexes (Rachez et al., 1999). [Pg.53]

Pike JW (1991) Vitamin D3 receptors structure and function in transcription. Anna RevNutr 11 189-216 Carlberg C (1996) The vitamin D3 receptor in the context of the nuclear receptor superfamily the central role of retinoid X receptor. Endocrine 4 91-105... [Pg.147]

Umesono K, Murakami KK, Thompson CC, Evans RM (1991) Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65 1255-1266 Carlberg C (1995) Mechanisms of nuclear signalling by vitamin D3 interplay with retinoid and thyroid hormone signalling. EurJ Biochem 231 517-527... [Pg.147]

Cheskis B, Freedman LP (1994) Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol Cell Biol 14 3329-3338... [Pg.148]

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