Virus-cell binding inhibitors inhibition

Viral Inhibitors. A multivalency approach was used to inhibit influenza virus in-fectivity. Several sialic acid-based polymers have been synthesized that inhibit flu virus receptor-binding activity, which in turn impedes flu viruses from sticking to cell surfaces and subsequent viral infection of cells (see also Section 2.1.4) (155,156). 

Abstract The inhibitory action of polyanionic substances on virus replication was reported more than 50 years ago. Seaweeds, marine invertebrates, and higher plants represent abundant sources of novel compounds of proved antiviral activity. Natural sulfated polysaccharides (SPs) are potent in vitro inhibitors of a wide variety of enveloped viruses, such as herpes simplex virus (HSV) types 1 and 2, human immunodeficiency virus (HIV), human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. Several polysulfate compounds have the potential to inhibit virus replication by blocking the virion binding to the host cell. In contrast, their in vivo efficacy in animal and human systemic infections has undesirable draw-... 

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