Vinblastine Zidovudine

Drug Interactions Zidovudine Probenecid Imipenem-cilastatin Dapsone Pentamidine Flucytosine Vincristine Vinblastine Adriamycin Amphotericin B TMP-SMX Other nucleoside analogues... 

VINCA ALKALOIDS ZIDOVUDINE t adverse effects when vincristine and possibly vinblastine are co administered with zidovudine Additive toxicity Use with caution. Monitor FBC and renal function closely. 1 doses as necessary... 

Clinically important, potentially hazardous interactions with abacavir, atorvastatin, bepridil, bupropion, carbamazepine, clarithromycin, cyclosporine, dexamethasone, digoxin, felodipine, fluticasone propionate, fosamprenavir, itraconazole, ketoconazole, lovastatin, methadone, midazolam, nicardipine, nifedipine, phenobarbital, phenytoin, rifabutin, simvastatin, sirolimus, St John s wort, systemic lidocaine, tacrolimus, tenofovir, trazodone, vinblastine, vincristine, voriconazole, warfarin, zidovudine... 

Zidovudine is rapidly absorbed from the G1 tract with peak serum concentrations occurring within 30 to 90 minutes. It binds to plasma proteins to the extent of 35 to 40%. Zidovudine is rapidly metabolized in the liver to the inactive 3 -azido-3 -deoxy-5 -0-beta-D-glucopyranuronosylthymi-dine (GAZT), which has an apparent elimination half-life of 1 hour. Zidovudine undergoes glomerular filtration and active tubular secretion. Coadministration of zidovudine with agents such as dapsone, pentamidine, amphotericin B, flucytosine, vincristine, vinblastine, adriamycin, and interferon with potential to cause nephrotoxicity or cytotoxicity to hematopoietic elements, enhance its risk of adverse effects. Probenecid will inhibit the renal excretion of zidovudine. 

A 55-year-old HIV-positive man who was taking zidovudine, lamivudine, ahaeavir, nevirapine and ritonavir-hoosted lopinavir experieneed unex-peeted severe gastrointestinal and haematological toxicities and moderate renal failure after the seeond and third intravenous injections of vinblastine 10 mg given to treat multicentric Castieman s disease (MCD). Subsequently, the antiretrovirals were stopped and the patient did not experience these toxicities when vinblastine was given alone. When the MCD was un-... 

In one preliminary report, the addition of vinblastine to zidovudine resulted in severe bone marrow depression. Similarly, 9 of 21 patients could not tolerate zidovudine while receiving a chemotherapy regimen (cyclophosphamide, doxorubicin, teniposide, prednisone, vincristine and bleomycin) because of haematological toxicity. ... 

Qiarakfaanian S, De SabbR, VaseghiM, Garden B, Rozenbaum W. Evaluation of the associ-ation of zidovudine and vinblastine in treatment of AEDS-related Kqx)si s sarcoma. 5 International Conference on AIDS, Montreal, 1989. Abstract MBP368. 

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