Venous stasis ulcers, treatment

Bishop JB, Phillips LG, Mustoe TA. A prospective randomized evaluator-bUnded trial of two potential wound healing agents for the treatment of venous stasis ulcers. J Vase Surg August 1992 16 251-7. 

Jung, S.B., Day, D.E., Day, T., Stoecker, W., and Taylor, P. (2011) Treatment of non-healing diabetic venous stasis ulcers with bioactive glass nanofibers. Wound Repair Regen., 19, A30 A40. 

Ethacridine (6,9-diamino-2-ethoxyacridine) is widely used in the local treatment of inflammatory or ulcerative conditions of the skin, particularly crural eczema due to venous stasis. Many publications point to the high frequency of exacerbation involving local allergic reactions and also generalized eczematous reactions (SEDA-11, 474). 

Venous insufficiency is the most common cause of leg ulcers. Venous insufficiency is often caused by deep thrombosis or weakness of the valve system of the lower leg superficial veins, but the wound may also be caused due to, for example, arterial circulatory disorders, vasculitis or diabetes. The first sign of venous insufficiency is lower leg swelling but also eczema around the ankle, caused by venous stasis, can be an early marker (Mayrovitz and Larsen, 1997). The most important treatment is to counteract the oedema condition, which can be done by keeping the leg in a raised position or by applying a compression bandage to the leg (Reichenberg and Davis, 2005 Rajendran et al., 2007). 

---