Venezuelan equine encephalomyelitis virus vaccine

Analogous results were obtained in monkeys using inactivated Venezuelan equine encephalomyelitis virus vaccine (Harrington et al., 1979). Figure 8 shows some of the data. It can be seen that antibody levels in serum were boosted about 40-fold after primary immunization when one compares levels attained after administration of vaccine along with poly(ICLC) with that attained with vaccine alone, and perhaps 200-fold after a secondary immunization. There was no alteration in the progression of IgM and IgG development. At the peak of antibody levels, most of the antibody was IgG. Polylysine complexed to carboxymethylcellulose, without poly I poly C, had no adjuvant action. 

Harrington, D.G., Crabbs, C.L., Hilmas, D.E., Brown, J.R., Higbee, G. A., Cole, F.E., Jr, and Levy, H.B., 1979, Adjuvant effects of low doses of a nuclease-resistant derivative of polyinosinic polyribocytidylic acid on antibody responses of monkeys to inactivated Venezuelan equine encephalomyelitis virus vaccine. Infect Immun 24 160. 

Monath TP, Cropp CB, Short WF, et al. Recombinant vaccinia-Venezuelan equine encephalomyelitis (VEE) vaccine protects nonhuman primates against parenteral and intranasal challenge with virulent VEE virus. Vac Res. 1992 1 55-68. 

Venezuelan equine encephalomyelitis virus (except the vaccine strain TC-83, see Appendix B-II-D (RG2))... 

Jochim MM, Barber TL, Luedke AJ. Venezuelan equine encephalomyelitis Antibody response in vaccinated horses and resistance to infection with virulent virus. J Am Vet Med Assoc. 1973 162(4) 280-283. 

Cole FE Jr, May SW, Eddy GA. Inactivated Venezuelan equine encephalomyelitis vaccine prepared from attenuated (TC-83 strain) virus. Appl Microbiol. 1974 27(1) 150-153. 

Venezuelan equine encephalomyelitis vaccine strain TC-83 Western equine encephalomyelitis virus... 

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