Vascular regeneration

Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S, Silver M, Li T, Isner JM, Asahara T. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002 105 732-738. 

Asahara T Isner JM, Endothelial progenitor cells for vascular regeneration. J Hematother Stem Cell Res 2002 II 171-178. 

Yi, C., Xia, W., Zheng, Y., Zhang, L., Shu, M., et al. 2006. Transplantation of endothelial progenitor cells transferred by vascular endothelial growth factor gene for vascular regeneration of ischemic flaps. J. Surg. Res. 135 100-106. 

Resisting vascular wall cell migration and hyperplasia. Vascular EC can be induced to resist SMC invasion. For this mechanism, besides the functions of EC-produced multiple factors, EC itself is also capable of migration with the cue of migrating factors secreted by platelets or leukocytes and the shear stress by blood flow. EC migration usually accompanies proliferation, which frequently relates to new vascular formation or defective vascular regeneration [100,101]. 

N. Grabow, D.P. Martin, K.-P. Schmitz, K. Sternberg, Absorbable polymer stent technolc ies for vascular regeneration, J. Chem. Technol. Biotechnol. 85 (2010) 744-751. 

Grabow, N., Martin, D.P., Schmitz, K.P., and Sternberg, K. (2010) Absorbable polymer stent technologies for vascular regeneration. /. Chem. Technol. BiotechnoL, 85, 744-751. 

Nakazawa Y, Sato M, Takahashi R, Aytemiz D, Takabayashi C, Tamura T, Enomoto S, Sata M, Asakura T. Development of small diameter vascular grafts based on silk fibroin fibers from Bombyx mori for vascular regeneration. J. Biomat. Set Polym. Ed. 22 195-206,2011. 

The neuromuscular complications of diabetes mellitus are most often neuropathic in origin, with distal sensorimotor polyneuropathies being the most common. In addition, ischemic infarction of skeletal muscle may occur due to occlusive vascular disease, with small and medium-sized arterioles particularly affected. This occurs in poorly-controlled diabetes and affects thigh, muscles in most cases. In acute stages, muscle biopsy findings are those of widespread muscle necrosis, edema, and phagocytic cell infiltration. Muscle regeneration may be incomplete and increased fibrous connective tissue may replace lost muscle tissue. 

The regenerative capacity of bone is robust and effective at addressing wounds under normal conditions. A proportion of fractures, however, present conditions that are not conducive to regeneration and place the fracture at high risk for nonunion or delayed union. For example, fractures located at sites of marginal vascularity and those associated with a large area of bone loss repair with difficulty if at all. As a result, a great deal of effort has been invested in the development of treatment methods for fractures and defects at risk of nonunion, as they would not likely heal... 

In the recent review Carr et al. [54] considered potential antiatherogenic mechanisms of a-tocopherol and ascorbic acid. These authors concluded that these antioxidants are able to inhibit LDL oxidation, leukocyte adhesion to the endothelium, and vascular endothelial dysfunction. They also believe that ascorbic acid is more effective than a-tocopherol in the inhibition of these pathophysiological processes due to its capacity of reacting with a wide spectrum of oxygen and nitrogen free radicals and its ability to regenerate a-tocopherol. 

Synthetic blood vessels and patches for soft tissue regeneration surgical sutures for use in vascular, cardiac, general surgery and orthopaedic procedures. .. 

In one reported case, thioglycolic acid accidentally splashed onto the eyes, face, legs, and arms caused second-degree burns of the skin. Within 2 hours the corneas became clouded and the conjunctivae was edematous. Over the course of several months the cornea cleared and necrotic conjunctiva regenerated and vascularized, leaving slightly impaired vision. 

Bilberry Vaccinium myrtillus) Uses Prevent/treat visual problems such as cataract, retinopathy, myopia, glaucoma, macular degeuCTation treat vascular problems such as hemorrhoids, varicose veins Actions Contains anthocyanidin that X vascular permeability, inhibit pit aggregation thrombus formation, t antioxidant effects on LDLs liver, t regeneration of rhodopsin... 

Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003 9 702-712. 

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