Vascular integrity

Hutcheson, I.R, Whittle, B.J.R. and Boughton-Smith, N.K. (1990). Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br. J. Pharmacol. 101, 815-820. 

Activation of endothelial cells leads to changes in endothehal ceU properties such as loss of vascular integrity, expression of adhesion molecules, antithrombotic to prothrombotic phenotype changes, cytokine production and the upregulation of HLA molecules. All these diverse effects can be attributed to the activation of transcription factors [44]. Of the presently known transcription factors, NFkB is believed to be one of the most important in the regulation of endothehal cell activation. After a stimulus at the cell surface which is caused by e.g. 

Insulin sensitivity Glucose homeostasis Vascular integrity... 

Evaluate the entire embryo for vascular integrity and any vascular anomalies. These are noted but not scored. 

Fig. 11. Vascular integrity evaluation, (a) Flemorrhage in forebrain area (arroW. (b) General pronounced vasculature and/or vascular congestion throughout embryo.

Anterola, A. M., and Lewis, N. G., 2002, Trends in lignin modification a compehensive analysis of the effects of genetic manipulations/ mutations on lignification and vascular integrity, Phytochem. 61 221-294. 

See color plate.) The primar/ hemostatic response. Following loss of vascular integrity platelets adhere to subendothelial wall matrix, which triggers their activation. Abbreviations HT, hydroxy tryptamine TFPI, tissue factor pathway inhibitor. 

Partial embryonic lethality 50 % between embryonic day (E) 9.5-11.5 at least 1/4 survive to term, but fatal hemorrhage few days after birth factor II important in maintaining vascular integrity during development as well as postnatal life (Sun et al. 1998 Xu et al. 1998). 

In patients with hemoptysis, the possibility that pyrazinamide may have an adverse effect on blood clotting time or vascular integrity should be borne in mind (12,13). 

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ et al (2013) Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer s disease. J Cereb Blood Flow Metab 33 1412-1421... 

No. Patients with type 1 diabetes may already have compromised vascular integrity. 

Juhas, M., Engelmayr Jr, G.C., Fontanella, A.N., Palmer, G.M., Bursae, N. Biomimet-ic engineered muscle with capacity for vascular integration and functional maturation in vivo. Proceedings of the National Academy of Sciences of the United States of America 111, 5508-5513 (2014)... 

Taken together, multiple studies have shown the production of a-halofatty aldehydes as a result of the activities of the peroxidases of neutrophils, monocytes, macrophages, eosinophils, and thyroid cells. These aldehydes are produced in response to inflammation and have been shown to alter important physiological processes including vascular integrity and cardiac contractile performance. 

Recent studies from our laboratory demonstrate an essential role for the p21 activated kinase (Pak) 1 in control of salivary gland lumen size through the cell-cell adhesion protein, E-cadherin. Pak proteins are serine-threonine kinases that control vascular integrity in zebrafish blood vessels (Buchner et al., 2007 Liu et al., 2007) and lumen formation by human endothelial cells cultured in three-dimensional collagen matrices (Koh et al., 2008 Koh et al., 2009). In the Drosophila embryonic salivary gland, Pakl functions downstream of the small... 

---