Vascular architecture

Chan LS, Malcontenti-Wilson C, Muralidharan V, Christophi C. (2008) Alterations in vascular architecture and permeability following OXi4503 treatment. Anti-Cancer Drugs 19 17-22. 

In diabetes the disruption of the normal vascular architecture and loss of capillaries may affect the efficiency of glucose transport to a sensor surface. The Fat Sand Rat may be a good model for such effects, as this species was reported by... 

Miodonski A, Bugajski A, Litwin J, Piasecki Z. Vascular architecture of human urinary bladder carcinoma A SEM study of corrosion casts. Virchows Arch 1998 433 145-151. 

Mann, L. L. Aberrant vascular architecture in tumours and its importance in drug-based therapies. Drug Discov. Today 2003, 8, 396 03. 

JONES, C.G., HOPPER, R.F., COLEMAN, J.S., KRISCHNIK, V.A., Control of systemically induced herbivore resistance by plant vascular architecture,... 

S.M. Ameer-Beg, P.R. Barber, R. Locke, R.J. Hodgkiss, B. Vojnovic, G.M. Tozer, J. Wilson, Application of multiphoton steady state and lifetime imaging to mapping of tumor vascular architecture in vivo, Proc. SPIE, 4620, 85-95 (2002)... 

Until recently, only phase-contrast and time-of-flight techniques were available to study the vascular system (Fig. 3.2). These have been demonstrated to be of value in providing three-dimensional representations of AVM vascular architecture (Marchal et al. 1990). However, these techniques... 

Defective vascular architecture for example, lack of smooth muscle layer cells, lack of or reduced receptors for angiotenrin II, large gap in endodielial cdl-celt junctions, anomalous conformation of tumor vasculature (branching or stretching etc.)... 

Although the details of the vascular architecture for particular organs have been well characterized in individual cases, variability among individuals makes the use of such published data valid only in a statistical sense. Current imaging technology can be used to map and numerically model thermally significant blood vessels larger than 600 /um diameter [6], but smaller vessels must be analyzed by other approaches as illustrated below. 

This occurs because of the abnormalities of tumor vasculature, namely hypervascularization, aberrant vascular architecture, extensive production of vascular permeability factors and lack of lymphatic drainage [4], which stimulate the extravasation of nanoparticles and the accumulation of drugs in the tumor inter-stitium, improving their therapeutic efficacy and reducing harmful non-specific side effects [5]. In addition, nanosized materials administered intravenously (i.v.) escape renal clearance due to their large size. 

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