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Vascular architecture

Chan LS, Malcontenti-Wilson C, Muralidharan V, Christophi C. (2008) Alterations in vascular architecture and permeability following OXi4503 treatment. Anti-Cancer Drugs 19 17-22. [Pg.169]

In diabetes the disruption of the normal vascular architecture and loss of capillaries may affect the efficiency of glucose transport to a sensor surface. The Fat Sand Rat may be a good model for such effects, as this species was reported by... [Pg.102]

Miodonski A, Bugajski A, Litwin J, Piasecki Z. Vascular architecture of human urinary bladder carcinoma A SEM study of corrosion casts. Virchows Arch 1998 433 145-151. [Pg.215]

Mann, L. L. Aberrant vascular architecture in tumours and its importance in drug-based therapies. Drug Discov. Today 2003, 8, 396 03. [Pg.811]

JONES, C.G., HOPPER, R.F., COLEMAN, J.S., KRISCHNIK, V.A., Control of systemically induced herbivore resistance by plant vascular architecture,... [Pg.143]

S.M. Ameer-Beg, P.R. Barber, R. Locke, R.J. Hodgkiss, B. Vojnovic, G.M. Tozer, J. Wilson, Application of multiphoton steady state and lifetime imaging to mapping of tumor vascular architecture in vivo, Proc. SPIE, 4620, 85-95 (2002)... [Pg.351]

Until recently, only phase-contrast and time-of-flight techniques were available to study the vascular system (Fig. 3.2). These have been demonstrated to be of value in providing three-dimensional representations of AVM vascular architecture (Marchal et al. 1990). However, these techniques... [Pg.68]

Defective vascular architecture for example, lack of smooth muscle layer cells, lack of or reduced receptors for angiotenrin II, large gap in endodielial cdl-celt junctions, anomalous conformation of tumor vasculature (branching or stretching etc.)... [Pg.31]

Although the details of the vascular architecture for particular organs have been well characterized in individual cases, variability among individuals makes the use of such published data valid only in a statistical sense. Current imaging technology can be used to map and numerically model thermally significant blood vessels larger than 600 /um diameter [6], but smaller vessels must be analyzed by other approaches as illustrated below. [Pg.98]

This occurs because of the abnormalities of tumor vasculature, namely hypervascularization, aberrant vascular architecture, extensive production of vascular permeability factors and lack of lymphatic drainage [4], which stimulate the extravasation of nanoparticles and the accumulation of drugs in the tumor inter-stitium, improving their therapeutic efficacy and reducing harmful non-specific side effects [5]. In addition, nanosized materials administered intravenously (i.v.) escape renal clearance due to their large size. [Pg.299]


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