Vaccines active immunotherapy

Bronte, V, Genetic vaccination for the active immunotherapy of cancer. Curr Gene Ther, 2001.1(1) 53-100. 

Active DNA Ap42 vaccination as immunotherapy for Alzheimer disease. Transl Neurosci 3 307-313... 

MacLean G. D. Reddish M. A. Longenecker B. M. Antibodies against mucin-associated sialyl-Tn epitopes correlate with survival of metastatic adenocarcinoma patients undergoing active specific immunotherapy with synthetic STn vaccine. J Immunotherapy 1996,19,9-68. 

Nicolette CA et al. Dendritic cells for active immunotherapy optimizing design and manufacture in order to develop commercially and clinically viable products. Vaccine 2007 25 S2 B47 0. 

Keywords Active vaccination Alzheimer s disease Amyloid Amyloid precursor protein Antibody titer Beta-pleated sheet Cerebral amyloid angiopathy Dementia Immunotherapy Monoclonal antibody Passive vaccination Senility... 

Conforti AM, Ollila DW, Kelley MC, et al. Update on active specific immunotherapy with melanoma vaccines. J Surg Oncol 1997 66 55-64. 

Morton DL, Foshag LJ, Hoon DS, et al. Prolongation of survival in metastatic melanoma after active specific immunotherapy withanewpoly-valent melanoma vaccine. Ann Surg 1992 216 463. 

Morisaki, T., K. Matsumoto, H. Onishi, H. Kuroki, E. Baba, A. Tasaki, M. Kubo, M. Nakamura, S. Inaba, K. Yamaguchi, M. Tanaka, and M. Katano (2003) Dendritic cell-based combined immunotherapy with autologous tumor-pulsed dendritic cell vaccine and activated T cells for cancer patients rationale, current progress, and perspectives. Hum Cell 16 175-182. 

Moss has another chapter about the use of MTH-68 vaccine, a unique form of immunotherapy developed by Laszlo K. Csatay, M.D., of Fort Lauderdale, Florida (Moss, 1992, pp. 437 44). It involves the interference between two viruses, which is a well-known phenomenon. One virus interferes with the activities of the other, in one way or another. The situation may also be looked upon as a case where one virus stimulates the immune system to destroy the other less desirable virus, the latter being the cause of the cancerous condition. 

The T-cells of many cancer patients are naturally sensitized to tumor-associated antigens or can readily be sensitized with even simple vaccination maneuvers. Adoptive immunotherapy (AIT) constitutes a coordinated effort to harvest and activate such T-cells, propagate them in culture, and adoptively transfer them back into patients as therapy. Recent modifications in culture techniques, coupled... 

Because tumor growth is associated with the progressive impairment of immunologic competence, a therapeutic goal is the enhancement of cell-mediated immunity. Cell-mediated immunity may be augmented by nonspecific stimulants such as levamisole, lymphokines, and interferon, which stimulate the antitumor activity of NK cells. Cell-mediated immunity may also be stimulated by specific stimulants such as vaccines, which are composed of killed or inactivated tumor cells or tumor cell fragments. The full range of immunotherapy s usefulness remains to be realized. 

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