Urine, glucose testing

LeBel M, Paone RP, Lewis GP. Effect of ten new beta-lactam antibiotics on urine glucose test methods. Drug Intell Clin Pharm 1984 18(7-8) 617-20. 

Rotblatt, M. D., and M. A. Koda-Kimble. 1987. Review of drug interference with urine glucose tests. Diabetes Care 10 103-110. 

Those with type 1 diabetes mellitus produce insulin in insufficient amounts and tiierefore must have insulin supplementation to survive Type 1 diabetes usually has a rapid onset, occurs before die age of 20 years, produces more severe symptoms tiian type 2 diabetes, and is more difficult to control. Major symptoms of type 1 diabetes include hyperglycemia, polydipsia (increased thirst), polyphagia (increased appetite), polyuria (increased urination), and weight loss. Treatment of type 1 diabetes is particularly difficult to control because of the lack of insulin production by die pancreas. Treatment requires a strict regimen tiiat typically includes a carefully calculated diet, planned physical activity, home glucose testing several times a day, and multiple daily insulin injections. 

SMBG Self-monitoring of blood glucose UPT Urine pregnancy test... 

Diabetic Rats-Phase I. Laboratory rats (CD strain, 250-300g, male) were made diabetic by a single injection of streptozotocin (STZ), 50 mg/kg, into the tail vein. Nondiabetic controls received an equal volume of citrate buffer. Twenty-four hours after the STZ injection, each rat was individually housed for urine collection. The appearance of glucose in the urine (Ames test strips) and a predictable weight loss or depression of the growth curve were taken as confirming evidence of diabetes. 

Drug/Lab test interactions Urine glucose and serum cholesterol levels may increase. Decreased serum levels of potassium, T3, and a minimal decrease of T4 may occur. 

Drug/Lab test interactions Thiazides may decrease serum PBI levels without signs of thyroid disturbance. Thiazides also may cause diagnostic interference of serum electrolyte, blood, and urine glucose levels (usually only in patients with a predisposition to glucose intolerance), serum bilirubin levels, and serum uric acid levels. In uremic patients, serum magnesium levels may be increased. Bendroflumethiazide may interfere with the phenolsulfonphthalein test due to decreased excretion. In the phentolamine and tyramine tests, bendroflumethiazide... 

Drug/Lab test interactions False-positive urine glucose reactions may occur with penicillin therapy if Clinitest, Benedict s Solution, or Fehling s Solution are used. It is recommended that enzymatic glucose oxidase tests (such as Clinistix or Tes-Tape) be used. Positive Coombs tests have occurred. High urine concentrations of some penicillins may produce false-positive protein reactions (pseudoproteinuria) with the P.870... 

Drug/Lab test interactions A false-positive reaction for urine glucose may occur with Benedict s solution, FeMng s solution, or with C//n/fesf tablets, but not with enzyme-based tests such as Clinistix and Tes-Tape. 

Lab test abnormalities include the following ALT, AST, creatine kinase, hematuria, neutrophils, serum amylase, serum glucose, triglycerides, urine glucose. 

A patient s urine was tested with Clinistix, and the color was read 60 sec. after wetting the strip. It showed 1.0% glucose in the urine. Is the patient diabetic Explain. 

A sample of Irene s urine was tested for glucose this test proved negative. A blood sample was sent off for determination of plasma vasopressin (ADH), which appeared to be within normal limits. Irene was also asked to collect a 24-hour urine sample for analysis. Her 24-hour urine volume was 6.51. 

Mayson JS, Schumaker O, and Nakamura RM (1973) False-negative tests for urine glucose. Lancet 1,780-1. 

Direct Test on Urine Glucose, ketones, and pH— Labstix test Dip a Labstix strip briefly into the urine and read after 10 to 15 seconds. For glucose, the result should be correlated with blood-glucose determination. A positive result for ketones may indicate intoxication by acetone or isopropyl alcohol. This test may also be positive in starvation or in diabetic ketosis. 

Ektachem Glucose Test Methodology (1981). Supplement I, Urine Samples. Ektachem Glucose Test Methodology (1981). Supplement 2, Cerebrospinal Fluid Samples. 

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