Uridine diphosphate acetylglucosamine

Pontis, H. G, Uridine Diphosphate Acetylglucosamine in Liver. J. biol. 

Cabib, E., Leloir, L.F. Cardini, C.E. (1953) Uridine Diphosphate Acetylglucosamine , Journal of Biological Chemistry, 203, 1055-70 Cabib, E., Ulane, R. Bowers, B. (1973) Yeast Chitin Synthetase. Separation of the... 

Strominger, J. L. Uridine diphosphate acetylglucosamine phosphate and uridine diphosphate acetylglucosamine sulfate. Biochem. biophys. Acta (Amst.) 17, 283 (1955). 

Two additional related derivatives of uridine-5-phosphate have recently been reported. Uridine diphosphate acetylglucosamine has been isolated from yeast. (Cabib, E., Leloir, L. F., and Cardini, C. E., J. Biol. Chem. 203, 1055 (1953).) Uridine diphosphate glucuronic acid is stated to be an active metabolite in glu-curonide formation. (Dutton, G. J. and Storey, I. D. E., Biochem. J. 63, xxxvii (1953).)... 

UDPG was the first of a whole new class of nucleotides, in which the uridine diphosphate group is attached to a monosaccharide. Two important members of the class are uridine diphosphate glucuronic acid, the intermediate in the synthesis of glucuronides and of many other compounds, and uridine diphosphate N-acetylglucosamine which is an intermediate in the synthesis of mucopolysaccharides. Uridine diphosphate muramic acid was isolated by Park (P2) from Staphylococcus aureus... 

Polyoxins such as polyoxin A, B and D which block the biosynthesis of chitin are competitive inhibitors of uridine diphosphate-N-acetylglucosamine [65]. In resistant isolates of Altemaria kikuchiana, no uptake of dipeptides was observed suggesting that altered dipeptide permease may be responsible for polyoxin resistance [65]. 

Tyro protein tyrosine kinase-binding protein, DNAX-activation protein 12, DAP12, KARAP Upstream activation site Ubiquitinlike modifiers Universal conditions direct sequencing Ubiquitin-domain proteins uridine diphosphate Uridine-5 -diphospho-iV-acetylglucosamine Uracil DNA glycosylase Upstream open reading frame... 

Gottlieb, C., Baenziger, J. and Komfeld, S. (1975). Deficient uridine diphosphate-N-acetylglucosamine glycoprotein N- acetylglucosaminyltransferase activity in a clone of Chinese hamster ovary cells with altered surface glycoproteins. J. Biol. Chem. 250, 3303-3309. 

Yamamoto, K., H. Kawai, and T. Tochikura. 1981. Preparation of uridine diphosphate-A-acetylgalactosamine from uridine diphosphate-A-acetylglucosamine by using microbial enzymes. Appl. Environ. Microbiol. 41 392-395. 

The most likely steps where benzoylureas may be active are the last two steps the assembly of Uridine diphosphate N-acetyl-glucosamine from UTP and N-acetylglucosamine-l-phosphate and the polymerization of N-acetylglucosamine from UDP-N-acetylglucosamine under the mediation of chitin synthetase. Since studies [Gijswijt, et al., 1979] have indicated that benzoylurea intoxication is accompanied by the buildup of UDP-N-acetylglucosamine, the latter... 

UDP-7V-acetylglucosamine (uridine diphosphate), nikkomycins act as potent competitive inhibitors of chitin synthase and exhibit potent fungicidal, insecticidal, and acaricidal activities [320]. Nikkomycin X and Z, isolated as major components, contain the hydroxypyridylhomothreonine (HPHT) moiety, the aminohexuronic acid, and a nucleoside moiety N-glycosidically linked to 4-formyl-imidazolin-2-one or a uracil base, respectively [321, 322]. 

Solvents in both cases, LON acetic acid (2 cm) and l.ON acetic acid-3.0M lithium chloride (90 + 10) (15 cm) times of run 120 min (TLC) and 60 min (PC). Visualisation in UV light amounts 10—100 (xmoles. a uridine monophosphate h uridine-diphosphate-N-acetylglucosamine c uridine diphosphate-glucose d uridine diphosphate. An unknown substance (i) appears on the thin-layer chromatogram which is not found on the paper chromatogram... 

Abeijon C, Mandon EC, Robbins PW, Hirschberg CB. A mutant yeast deficient in Golgi transport of uridine diphosphate N-acetylglucosamine. J. Biol Chem. 1996 277 8851 8854. 

Abeijon C, Robbins PW, Hirschberg CB. Molecular cloning of the Golgi apparatus uridine diphosphate-N- acetylglucosamine transporter from Kluyveromyces lactis. Proc. Natl Acad. Sci. U.S.A. 1996 95 5963-5968. 

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