Adhesion to bone

The use of such an ethylene/acrylate copolymer provides a number of advantages. The ethylene portion of the copolymer is particularly well suited for adhering to the PE of the first polymer layer during fusion of the first polymer layer and the second polymer layer to one another. Further, the acrylate portion of the copolymer is particularly well suited for adhesion to bone cement, such as bone cement that includes poly(methyl methacrylate). Thus, using such a copolymer in the construction provides for ease of implantation in regard to a bearing designed for cement fixation. 

Wong, E.W. Bennington, A.G. A Percutaneous Implant Using a Porous Metal Surface Coating for Adhesions to Bone and a Velour Covering for Soft Tissue Attachment, Results of Trials in Pigs, J. Biomed. Mat. Res., 1977, 11, 883. ... 

G.M. Brauer, C.H. Lee, Oligomers with pendant isocyanate groups as tissue adhesives. 2. Adhesion to bone and other tissues, J. Biomed. Mater. Res. 23 (July 1989) 753-763. 

Hench, LL Clark, AE. Adhesion to bone. In Williams DF editor. Biocompatibility of Orthopedic Implants Vol. 2. Boca Raton CRC Press Inc., 1982 129-170. 

Three months after implantation, the most of BCP scaffolds of group B (Fig. 5) were disappeared extensively and no traces of periosteal and intercortical callus were observed anymore. However, the samples of group A were remained almost intact but displayed an interfacial adhesion to bone though. 

High level of adhesion to bone, often in the presence of contaminants such as fats and, proteins... 

Levy, O.L.. Martinowilz, U., Oran, A., Tauber, C. and Horoszowski, H., The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty a prospective, randomized, mullicenter study. J. Bone Joint Surg.. 81A. 1580 (1999). 

Adhesion in vivo appears to be dynamic. Bonding to bone was observed to be disrupted as extensive bone remodelling took place, and then reestablished once damage had been repaired (Brook, Craig Lamb, 1991b). 

CXCL12. In addition to chemoattractants, adhesion molecules play critical roles in HSPC homing to bone marrow. It should be appreciated that the CXCL 12-dependent homing of HSPCs to marrow also involves adhesion molecules. 

Frenette PS, Subbarao S, Mazo IB, von Andrian UH, Wagner DD. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A 1998 95(24) 14423-14428. 

In particular, the ethylene portion of the copolymer is compatible with and provides for adhesion to the PE of the first layer, whereas the acrylate portion of the copolymer is compatible with and provides for adhesion to commonly utilized bone cements. 

T. Tally, Bio-adhesive composition, method for adhering objects to bone, US Patent 6,533,821 Bl, 2003. 

Much inflammation in asthma is thought to be a consequence of the inappropriate accumulation of eosinophils and the subsequent release of their potent proinflammatory arsenal that includes such diverse elements as granule-derived basic proteins, mediators, cytokines, and chemokines (5). Interleukin (lL)-5 is cmcial to the development and release of eosinophils from the bone marrow, their enhanced adhesion to endothelial cells that line the postcapillary venules, and their persistence, activation, and secretion in the tissues. Several animal models of asthma including the use of primates have provided good evidence... 

CD34 cell-cell adhesion molecule and cell surface glycoprotein. May mediate attachment of stem cells to bone marrow exdracellular maddx or direedy to sd omal cells. Consdtudvely expressed on endothelial cells. 

The viscous isoamyl cyanoacrylate shows the least deterioration of bond strength to bone in an aqueous environment. This material has the further advantage that (1) it may be more suitable for applications where some filling of a gap by the adhesive is required and (2) it is considered to be less toxic than the lower homologues of the 2-cyanoacrylate series. 

The adhesion tests were conducted with flat, well-mated substrate specimens to minimize the effect of mechanical interlocking of the adhesive to the substrate. However, with bone containing surface pits, greater tensile adhesion values were obtained. Bone etched with 37% phosphoric acid prior to applying the adhesive did not improve joint strength. 

Experiments were performed to determine if monomers containing 2-cyanoacrylates were grafted, that is bonded covalently, to bone. Bone slabs were primed with 1% solution of triethylamine in n-hexane, and an ethyl cyanoacrylate was spread on the treated bone. Two hours after application of the adhesive, the attenuated total reflectance infrared spectrum showed clearly the presence of... 

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