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Ubiquitin gene expression

One important function of DUBs is the processing of ubiquitin or ubiquitin-like proteins to their mature forms. Ubiquitin is expressed in cells as either linear poly-ubiquitin or N-terminally fused to certain ribosomal proteins [79, 80]. These gene products are processed by DUBs to separate the ubiquitin into monomers and expose the gly-gly motif at the G-terminus. Many DUBs process linear polyubiquitin or Ub-fusion proteins in vitro, but this processing appears to take place cotransla-tionally in vivo and is extremely rapid. This makes analysis difficult and leaves unanswered the question of which DUBs actually perform this function in vivo. Multiple DUBs may be able to perform this processing at a physiologically relevant level since DUB deletions rarely shows processing defects [81]. [Pg.203]

Shi Y, Lan L, Matson C, Mulhgan P, Whetstine JR, Cole PA, Casero RA, Shi Y (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSDl. Cell 119 941-953 Shilatifard A (2006) Chromatin Modifications by Methylation and Ubiquitination Implications in the Regulation of Gene Expression. Annu Rev Biochem 75 243-269 Sterner DE, Berger SL (2000) Acetylation of histones and transcription-related factors. Microbiol. Mol Biol Rev 64 435-459... [Pg.368]

The covalent modifications of histone tails such as acetylation, phosphorylation, and ubiquitination have been shown to be reversible. This reversibility help the cells to respond to these regulatory modifications and thereby, influence the gene expression. Methylation of histones however, has been considered to be a relatively stable and irreversible mark on histones. Nevertheless active turnover of methyl groups on histones do exist. One of the possible mechanism of removal of methyl... [Pg.400]

Li FN, Johnston M (1997) Grrl of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skpl coupling glucose sensing to gene expression and the cell cycle. EMBO J 16 5629-5638 Li SJ, Hochstrasser M (1999) A new protease required for cell-cycle progression in yeast. Nature 398 246-251... [Pg.153]

Conaway, R.C., Brower, C.S., Conaway, J.W. (2002) Gene expression—emerging roles of ubiquitin in transcription regulation. Science 296, 1254-1258. [Pg.1118]

Combaret, L., Taillandier, D., Voisin, L., Samuels, S.E., Boespflug-Tanguy, O., and Attaix, D., 1996, No alteration in gene expression of components of the ubiquitin-proteasome proteolytic pathway in dystrophin-deficient muscles, FEBS Lett, 393, pp 292-296. [Pg.456]

The presence of tumor necrosis factor a directly leads to apoptosis via interaction with the tumor necrosis factor receptor, one of a class of receptors referred to as death receptors. NF-kB, which must enter the nucleus to initiate apoptosis, is a transcription factor sequestered in the cytoplasm by inhibitor of kB (IkB). The binding of TNFa to its receptor leads to the ubiquitin-dependent proteolysis of IkB, allowing NF-kB to enter the nucleus. The activation of apoptosis results directly from the stimulation of NF-kB, a transcription factor whose phosphorylation is controlled by vanadium compounds. In a global gene expression study, it was found that diabetes increased the formation of IkB, whereas vanadium compound treatment lowered the production of this inhibitor [101]. The activation of the TNFR also activates the caspase proteins, a class of proteases that cleave proteins after specific aspartate residues. [Pg.198]

In summary, gene expression studies have demonstrated the involvement of the ubiquitin/proteasome pathways, and dysregulation of mitochondria and cytoskeletal structures, supporting previous hypotheses. One of the novel findings that MN are trying to reenter cell division is surprising as in... [Pg.276]

Figure 2. Distribution of gene expression data from 50 prostatectomy samples measured with the U95Av2 Affymetrix microarray (a) histogram of the expression level of the HSYUBG1 Homo sapiens ubiquitin gene (b) histogram of the same gene expression level after the log-transformation was used. Figure 2. Distribution of gene expression data from 50 prostatectomy samples measured with the U95Av2 Affymetrix microarray (a) histogram of the expression level of the HSYUBG1 Homo sapiens ubiquitin gene (b) histogram of the same gene expression level after the log-transformation was used.
Mizutani A, Nakagawa N, Hitomi K, and Tsukagoshi N (1997) Ascorbate-dependent expression of ubiquitin genes in guinea pigs. International Journal of Biochemistry and... [Pg.440]


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See also in sourсe #XX -- [ Pg.48 , Pg.49 ]




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