Histone demethylation

Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (2006) Histone demethylation by a family of JmjC domain-containing proteins. Nature 439 811-816 van Holde K, Yager T (2003) Models for chromatin remodeling a critical comparison. Biochem Cell Biol 81 169-172... 

Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSDl. Cell 119 941-953 Sims RJ 3rd, Reinberg D (2006) Histone H3 Lys 4 methylation Caught in a bind Genes Dev. 20 2779-2786... 

In contrast, lysine methylation seems to be an exceptionally stable modification. Early studies showed that turnover of histone methyl groups was even slower than turnover of the histones themselves (e.g., [26,27]). No conclusive evidence has yet been found for histone demethylating enzymes, and they may not exist [28]. It may be that removal of methylated histones mostly occurs passively, through post-replication chromatin assembly and replacement of old, methylated histones with new, unmethylated ones. However, the possibility remains that local methylation patterns may be more dynamic and may involve novel mechanisms for removal of methylated tails [28]. 

Tomchick, D.R., Machius, M., Cole, P.A. and Yu, Fi. (2007) Structural basis of histone demethylation by LSDl revealed by suicide inactivation. Nature Structural si Molecular Biology, 14 (6), 535-539. 

Fomeris, F., Binda, C., Vanoni, M.A., Mattevi, A. and Battaglioli, E. (2005) Histone demethylation catalysed by LSDl is a flavin-dependent oxidative process. FEES Letters, 579, 2203-2207. 

Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M.E., Borchers, C.H.,Tempst, P. and Zhang, Y. (2006) Histone demethylation by a family of J mj C domain-containing proteins. Nature, 439,811-816. 

Klose RJ, Kallin EM, Zhang Y. JmjC-domain-containing proteins and histone demethylation. Nat. Rev. Genet. 2006 7 715-727. Benevolenskaya EV. Histone H3K4 demethylases are essential in development and differentiation. Biochem. Cell Biol. 2007 85 435-443. 

Shi Y, et al. Histone demethylation mediated by the nuclear 110. amine oxidase Homolog ESDI. Cell 2004 119 941-953. 

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