Potato carboxypeptidase inhibitor

Bayes, A., de la Vega, M. R., Vendrell, J., Aviles, F. X., Jongsma, M. A., Beekwilder, J. (2006). Response of the digestive system of Helicoverpa zea to ingestion of potato carboxypeptidase inhibitor and characterization of an uninhibited carboxypeptidase B. Insect Biochem. Mol. Biol., 36,654-664. 

Blanco-Aparicio, C., Molina, M. A., Femandez-Salas, E., Frazier, M. L., Mas, J. M., Querol, E., Aviles, F. X., de Llorens, R. (1998). Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. J. Biol. Chem., 273, 12370-12377. 

Wang, X., Smith, P. L., Hsu, M. -Y, Ogletree, M. L., Schumacher, W. A. (2006). Murine model of ferric chloride-induced vena cava thrombosis evidence for effect of potato carboxypeptidase inhibitor. J. Thromb. Haemost., 4, 403 10. 

Nilges, M., Gronenborn, A. M., Brunger, A. T. and Clore, G M. (1988). Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2. Protein Eng. 2, 27-38. 

M. anisopliae carboxipeptidase carboxypeptidase 30 9.97 DIFP, 1,10-phenan-throline, potato carboxypeptidase inhibitor St. Leger etal. (1994b)... 

Several plant proteins have been isolated that inhibit the metalloprotease carboxypeptidase A [205-217] (Table 7), notably potato carboxypeptidase inhibitor PCI [207-217] (Table 7). PCI is a small, cysteine-rich protein with a compact knotted structure determined by 3 disulphide links. The C-terminal region inserts into the active site of the carboxypeptidase. The C-terminal glycine is cleaved and remains trapped in the active site, this representing an example of suicide inactivation [207-216]. 

Solanum tuberosum (potato) (Solanaceae) Potato carboxypeptidase inhibitor (PCI) (= PCIA [Pg.596]

M. Nilges, A. M. Gronenborn, A. T. Brunger, and G. M. Clore, Protein Engin., 2,27 (1988). Determination of Three-Dimensional Structures of Proteins by Simulated Annealing with Interproton Distance Restraints. Application to Crambin, Potato Carboxypeptidase Inhibitor, and Barley Serine Proteinase Inhibitor 2. 

Interproton Distance Restraints. Application to Crambin, Potato Carboxypeptidase Inhibitor, and Barley Serine Proteinase Inhibitor 2. 

Solanum PCI (= Potato Carboxypeptidase Inhibitor) (4kDa protein)... 

The metalloprotease carboxypeptidase catalyses the removal of C-terminal residues and is structurally related to the PM-located epidermal growth factor (EGF) receptor tyrosine kinase (see Chapter 8). Several plant carboxypeptidase inhibitor proteins have been characterized and the potato carboxypeptidase inhibitor (PCI) is also an EGF receptor antagonist (Table 13.4). 

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