Tumor cells glycolysis

Chesney, J. Mitchell, R. Benigni, F. Bacher, M. Spiegel, L. Al-Abed, Y. Han, J.H. Metz, C. Bucala, R. An inducible gene product for 6-phospho-fructo-2-kinase with an AU-rich instability element role in tumor cell glycolysis and the Warburg effect. Proc. Natl. Acad. Sci. USA, 96, 3047-3052 (1999)... 

B. Chance, D. Garfinkel, J. Higgins, and B. Hess, Metabolic control mechanisms A solution for the equations representing interaction between glycolysis and respiration in ascites tumor cells. 

Partial inhibition of glycolysis by saturated fatty acids has been observed in Ehrlich ascites tumor cells. Palmitate and acetate decreased glutamate formation from glutamine (the first step in glutaminolysis) in this cell line, suggesting the possible role of fatty acids as an alternative energy source (Butler et al., 1999). 

Broxterman, H.J., Pinedo, H.M., Kuiper, C.M., Schuurhuis, G.J. and Lankelma, J. (1989) Glycolysis in P-glycoprotein-overexpressing human tumor cell lines. Effects of resistance-modifying agents. FEBS Letters, 247, 405-410. 

NDGA has been shown to have antitumor activity in vivo and in vitro. It is a powerful cancer antimetabolite producing in vitro complete inhibition of aerobic and anaerobic glycolysis and respiration of suspensions of several types of tumor cells including leukemia types. In vivo, NDGA combined with ascorbic acid is reported to reduce... 

An enzyme that hydrolyzes ATP (an ATPase) bound to the plasma membrane of certain tumor cells has an abnormally high activity. How will this activity affect the rate of glycolysis Explain why no net oxidation occurs during anaerobic glycolysis followed by lactate fermentation. 

M. Wu, A. Neilson, A. L. Swift, R. Moran, J. Tamagnine, D. Parslow, S. Armistead, K. Lemire, J. Orrell, J. Teich, S. Chomicz, and D. A. Ferrick, Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am. J. Physiol. Cell. Physiol, 292 (2007) C125-36. 

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