Tuberculosis Cent

A study of the effects of administering isonicotinic acid hydrazide to 173 tuberculosis patients for 3 months resulted in the following observations no toxicity, 62 per cent increased reflexes, 13 per cent tremor of limbs, 12 per cent twitching of legs, 1 per cent drowsiness, 8 per cent difficulty in urination, 2 per cent constipation, 5 per cent nervousness, 2 per cent flushing of face, 2 per cent skin rashes, 2 per cent.41... 

In view of the probable differences in the vulnerability of different tissues in different individuals, it may well be that the vitamin C needs for best health could vary from individual to individual more than the amount of vitamin C necessary for tissue saturation. It may easily be the case, for example, that some individuals are healthy and free from minor symptoms when their tissues are 50 per cent saturated Others, because of the greater vulnerability of specific tissues may require that their tissues be highly saturated at all times. Dalldorf 49 hints at something like resistant vitamin C deficiency when he says, "Even these large amounts [75 to 100 mg. daily], however, are inadequate to maintain saturation in certain patients" (italics added). He cites that in Hodgkins disease, protracted fever from various causes, active rheumatic heart disease, and tuberculosis, the vitamin C requirement may be "extremely high."... 

In a report by MSF, of 1,223 new chemical entities marketed between 1975 and 1997, only 13 (1 per cent) were specifically for tropical diseases, and just four could be considered to be products resulting directly from research activities of the pharmaceutical industry (Pecoul et al. 1999). More recently, the DND-WG and the HSPH sent questionnaires to the world s top 20 pharmaceutical companies to assess the level of R D activity in five neglected diseases sleeping sickness, leishmaniasis, Chagas disease, malaria and tuberculosis. Thirteen companies responded, eleven of which completed the questionnaire. In fiscal 2000, eight of the eleven spent nothing on... 

Isoniazid (11,31). This substance, the hydrazide of isonicotinic acid, is the keystone of the modern treatment of tuberculosis. It has an affinity for the ions of heavy metals of the same order as that of glycine. The complexes (11.33) of isoniazid are formed through the anion (11,32). No anion can be formed by the methyl-derivative N-methyl-N-isonicotinoylhydra-zine (11.34), tid this substance has virtually no antitubercular activity (Cymerman-Craig and Willis, 1955 Cymerman-Craig et al., 1955). Thus isoniazid inhibited Mycobacterium tuberculosis Rv. (in vitro, in the presence of 10 per cent of serum) at M/5000000, but substance (11.34) was inactive. 

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